• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Evidence-based complementary and alternative medicine: eCAM >Ligmosus rhinocerns (Cooke) Ryvarden: A Medicinal Mushroom That Stimulates Neurite Outgrowth in PC-12 Cells
【24h】

Ligmosus rhinocerns (Cooke) Ryvarden: A Medicinal Mushroom That Stimulates Neurite Outgrowth in PC-12 Cells

机译：Ligmosus rhinocerns（Cooke）Ryvarden：一种药用蘑菇，刺激PC-12细胞中的神经突生长。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A national treasure mushroom, Lignosus rhinocerus, has been used to treat variety of ailments by local and indigenous communities in Malaysia. The aim of this study was to investigate the potential of the most valuable part of L. rhinocerus, the sclerotium, on neurite outgrowth activity by using PC-12Adh cell line. Differentiated cells with one thin extension at least double the length of the cell diameter were scored positive. Our results showed that aqueous sclerotium L. rhinocerus extract induced neurite outgrowths of 24.4% and 42.1% at 20 mug/mL (w/v) of aqueous extract alone and a combination of 20 mug/mL (w/v) aqueous extract and 30 ng/mL (w/v) of NGF, respectively. Combination of NGF and sclerotium extract had additive effects and enhanced neurite outgrowth. Neuronal differentiation was demonstrated by indirect immunofluorescence of neurofilament protein. Aqueous sclerotium extract contained neuroactive compounds that stimulated neurite outgrowth in vitro. To our knowledge this is the first report on neurite-stimulating activities of L. rhinocerus.
机译：马来西亚的国宝蘑菇Lignosus rhinocerus已被用于治疗当地和土著社区的各种疾病。这项研究的目的是通过使用PC-12Adh细胞系研究犀牛最有价值的部分-菌核，对神经突生长的潜力。具有一个细延伸至少两倍于细胞直径长度的分化细胞被评为阳性。我们的结果表明，在仅20杯/ mL（w / v）的水提取物以及20杯/ mL（w / v）的水提取物和30杯水的组合下，巩膜水菌犀牛提取物诱导的神经突增生分别为24.4％和42.1％。 ng / mL（w / v）的NGF。 NGF和菌核提取物的组合具有累加作用并增强了神经突的长出。通过神经丝蛋白的间接免疫荧光证明了神经元的分化。菌核提取物含有神经活性化合物，可在体外刺激神经突生长。就我们所知，这是关于犀牛神经突刺激活动的首次报道。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号