Effect of first-generation perphenazine and second-generation antipsychotics on depressive symptoms in schizophrenia: all antipsychotics improved symptoms; quetiapine was superior to risperidone for people with major depression at baseline.

Dollfus S

首页> 外文期刊>Evidence-based mental health >Effect of first-generation perphenazine and second-generation antipsychotics on depressive symptoms in schizophrenia: all antipsychotics improved symptoms; quetiapine was superior to risperidone for people with major depression at baseline.

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Effect of first-generation perphenazine and second-generation antipsychotics on depressive symptoms in schizophrenia: all antipsychotics improved symptoms; quetiapine was superior to risperidone for people with major depression at baseline.

机译：第一代奋乃静和第二代抗精神病药对精神分裂症抑郁症状的影响：所有抗精神病药均可改善症状;对于基线严重抑郁的患者，喹硫平优于利培酮。

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Question: Are second-generation antipsychotics (SGAs) effective for the treatment of depressive symptoms in chronic schizophrenia? And does this effect differ from first-generation perphenazine?Patients: 1424 people with DSM-IV schizophrenia who were able to take an oral antipsychotic medication. Exclusions: people with schizoaffective disorder, mental retardation or other cognitive disorders, unstable serious medical condition, past adverse reactions to a proposed treatment, treatment-resistant schizophrenia and first episode of schizophrenia, and individuals who were pregnant or breastfeeding. Setting: Multiple sites in the USA; January 2001 and December 2004.

机译：问题：第二代抗精神病药（SGA）是否有效治疗慢性精神分裂症的抑郁症状？患者：1424例可以服用口服抗精神病药的DSM-IV精神分裂症患者。排除：患有分裂情感障碍，智力低下或其他认知障碍，不稳定的严重医学状况，过去对拟议治疗的不良反应，耐精神分裂症和精神分裂症的首发发作的人，以及怀孕或母乳喂养的人。地点：美国有多个站点; 2001年1月和2004年12月。

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《Evidence-based mental health》 |2011年第3期|共1页
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Dollfus S;
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中图分类神经病学与精神病学;
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1. Effect of first-generation perphenazine and second-generation antipsychotics on depressive symptoms in schizophrenia: all antipsychotics improved symptoms; quetiapine was superior to risperidone for people with major depression at baseline. [J] . Dollfus S Evidence-based mental health . 2011,第3期

机译：第一代奋乃静和第二代抗精神病药对精神分裂症抑郁症状的影响：所有抗精神病药均可改善症状;对于基线严重抑郁的患者，喹硫平优于利培酮。
2. Impact of second-generation antipsychotics and perphenazine on depressive symptoms in a randomized trial of treatment for chronic schizophrenia. [J] . Addington DE, Mohamed S, Rosenheck RA, The journal of clinical psychiatry . 2011,第1期

机译：在慢性精神分裂症的一项随机试验中，第二代抗精神病药和奋乃静对抑郁症状的影响。
3. Clozapine improves symptoms but not quality of life compared with other second-generation antipsychotics in people with treatment resistant schizophrenia [J] . Shon-W Lewis Evidence-based mental health . 2007,第2期

机译：与其他第二代抗精神病药相比，氯氮平可改善精神分裂症患者的症状，但不能改善生活质量
4. The impact of efficacious treatments for major depressive disorder on remission rates of specific symptoms: A re-analysis of the Treatment of Depression Collaborative Research Program. [D] . Stewart, Jeremy Gordon. 2009

机译：有效治疗重度抑郁症对特定症状缓解率的影响：《抑郁症治疗合作研究计划》的重新分析。
5. Impact of Second-Generation Antipsychotics and Perphenazine on Depressive Symptoms in a Randomized Trial of Treatment for Chronic Schizophrenia [O] . Donald E. Addington, Somaia Mohamed, Robert A. Rosenheck, -1

机译：在治疗的随机对照试验对慢性精神分裂症的抑郁症状的第二代抗精神病药奋乃静的影响
6. Impact of Second-Generation Antipsychotics and Perphenazine on Depressive Symptoms in a Randomized Trial of Treatment for Chronic Schizophrenia [O] . Donald E. Addington, Somaia Mohamed, Robert A. Rosenheck, 2010

机译：第二代抗精神病药和乳烯嗪对慢性精神分裂症治疗的随机试验中的抑郁症状的影响

Effect of first-generation perphenazine and second-generation antipsychotics on depressive symptoms in schizophrenia: all antipsychotics improved symptoms; quetiapine was superior to risperidone for people with major depression at baseline.

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