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首页> 外文期刊>Expert opinion on biological therapy >Bioreactor-free tissue engineering: directed tissue assembly by centrifugal casting.
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Bioreactor-free tissue engineering: directed tissue assembly by centrifugal casting.

机译：无生物反应器的组织工程：通过离心铸造进行定向组织组装。

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Casting is a process by which a material is introduced into a mold while it is liquid, allowed to solidify in a predefined shape inside the mold, and then removed to give a fabricated object, part or casing. Centrifugal casting could be defined as a process of molding using centrifugal forces. Although the centrifugal casting technology has a long history in metal manufacturing and in the plastics industry, only recently has this technology attracted the attention of tissue engineers. Initially, centrifugation was used to optimize cell seeding on a solid scaffold. More recently, centrifugal casting has been used to create tubular scaffolds and both tubular and flat multilayered, living tissue constructs. These newer applications were enabled by a new class of biocompatible in situ crosslinkable hydrogels that mimic the extracellular matrix. Herein the authors summarize the state of the art of centrifugal casting technology in tissue engineering, they outline associated technological challenges, and they discuss the potential future for clinical applications.
机译：铸造是一种过程，通过该过程将材料在处于液态的同时引入模具中，使其在模具内部固化为预定的形状，然后将其移除以制成加工好的物体，零件或壳体。离心铸造可以定义为利用离心力进行成型的过程。尽管离心铸造技术在金属制造和塑料行业中具有悠久的历史，但直到最近，该技术才引起了组织工程师的注意。最初，离心用于优化细胞在固体支架上的接种。最近，离心铸造已用于制造管状支架以及管状和扁平多层活组织构造。这些新的应用通过模拟细胞外基质的新型生物相容性原位可交联水凝胶实现。作者在此总结了组织工程中离心铸造技术的最新发展，概述了相关的技术挑战，并讨论了临床应用的潜在未来。

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