The hunger hormone ghrelin in cachexia.

Alessio Molfino; Gianfranco Gioia; Maurizio Muscaritoli

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The hunger hormone ghrelin in cachexia.

机译：饥饿激素生长激素释放肽在恶病质中。

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Cachexia is characterized by reduced food intake, muscle and adipose tissue loss associated with increased energy expenditure. Cachexia is highly prevalent and represents one of the main causes of increased morbidity, mortality and reduced quality of life in chronic diseases. Ghrelin plays an important role in stimulating and controlling hunger and maintaining energy homeostasis acting on central nervous system and on peripheral tissues. Most of the studies have been conducted in experimental settings and in cancer and uremic patients, showing interesting results in the treatment of cachexia. Further investigations are mandatory to obtain more definitive and conclusive results.

机译：恶病质的特征在于食物摄入减少，肌肉和脂肪组织损失与能量消耗增加有关。恶病质非常普遍，并且代表慢性病发病率，死亡率增加和生活质量下降的主要原因之一。 Ghrelin在刺激和控制饥饿以及维持作用于中枢神经系统和周围组织的能量稳态方面起着重要作用。大多数研究是在实验环境以及癌症和尿毒症患者中进行的，在恶病质的治疗中显示出有趣的结果。必须进行进一步的调查才能获得更确定的结论性结果。

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《Expert opinion on biological therapy》 |2013年第4期|共4页
作者
Alessio Molfino; Gianfranco Gioia; Maurizio Muscaritoli;
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正文语种 eng
中图分类治疗学;
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1. The hunger hormone ghrelin in cachexia. [J] . Alessio Molfino, Gianfranco Gioia, Maurizio Muscaritoli Expert opinion on biological therapy . 2013,第4期

机译：饥饿激素生长激素释放肽在恶病质中。
2. Fat Mass and Obesity-Associated Gene (FTO) Is Linked to Higher Plasma Levels of the Hunger Hormone Ghrelin and Lower Serum Levels of the Satiety Hormone Leptin in Older Adults [J] . Christian Benedict, Tomas Axelsson, Stefan Soederberg, Diabetes . 2014,第11期

机译：脂肪与肥胖相关基因（FTO）与老年人的饥饿激素Ghrelin的较高血浆水平和较低水平的饱腹激素瘦素的血清水平相关
3. Cocaine Blocks Effects of Hunger Hormone, Ghrelin, Via Interaction with Neuronal Sigma-1 Receptors [J] . Aguinaga David, Medrano Mireia, Cordomi Arnau, Molecular Neurobiology . 2019,第2期

机译：可卡因阻断饥饿激素，Ghrelin，通过与神经元Sigma-1受体相互作用的影响
4. Serum Leptin and Ghrelin Levels and their Relationship with Serum Cortisol, Thyroid Hormones, Lipids, Homocysteine and Folic Acid in Dogs with Compulsive Tail Chasing [C] . International Veterinary Behaviour Meeting . 2017

机译：血清瘦素和Ghrelin水平及其与血清皮质醇，甲状腺激素，脂质，同颗粒的关系，狗的强迫尾部追逐
5. The Hunger Hormone Ghrelin Dynamically Tunes Phasic Mesolimbic Signals Underlying Food-Directed Behaviors. [D] . Cone, Jackson J. 2014

机译：饥饿激素Ghrelin可以动态地调节基于食物的行为所依据的阶段性中胚层信号。
6. Similarities in Metabolic Flexibility and Hunger Hormone Ghrelin Exist between FTO Gene Variants in Response to an Acute Dietary Challenge [O] . Jessica Danaher, Christos G. Stathis, Matthew B. Cooke 2019

机译：FTO基因变异对急性饮食挑战的反应之间的代谢灵活性和饥饿激素生长素释放肽之间的相似性。
7. Cocaine Blocks Effects of Hunger Hormone, Ghrelin, Via Interaction with Neuronal Sigma-1 Receptors [O] . David Aguinaga, Mireia Medrano, Arnau Cordomí, 2018

机译：可卡因阻断饥饿激素，Ghrelin，通过与神经元σ-1受体的相互作用的影响

The hunger hormone ghrelin in cachexia.

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