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The emerging therapeutic role of antibody mixtures

机译：抗体混合物的新兴治疗作用

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摘要

A body of evidence suggests that a mixture of therapeutic monoclonal antibodies (mAbs) may be better than a single antibody. Several strategies have been developed to achieve multiple targeting, including the administration of two or more mAbs to the patient, bispecific antibodies and antibody mixtures. Recently, new antibody technologies based on a diverse array of antibodies binding to several different epitopes on any given antigen or antigens have been developed. One of the most promising is the Sympress? manufacturing technology, which allows the production of an antibody mixture in just one bioreactor as a single drug substance. Recombinant antibody mixtures may be applicable to therapy of neoplastic, autoimmune and infectious diseases.
机译：大量证据表明，治疗性单克隆抗体（mAb）的混合物可能比单一抗体更好。已经开发出几种策略来实现多重靶向，包括向患者施用两种或更多种mAb，双特异性抗体和抗体混合物。近来，已经开发了基于结合到任何给定一种或多种抗原上的几个不同表位的抗体的多样化阵列的新抗体技术。最有前途的之一是Sympress吗？制造技术，它允许仅在一个生物反应器中将抗体混合物作为单一药物生产。重组抗体混合物可用于治疗肿瘤，自身免疫和感染性疾病。

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