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首页> 外文期刊>Expert opinion on biological therapy >Certolizumab pegol in the treatment of Crohn's disease.
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Certolizumab pegol in the treatment of Crohn's disease.

机译：Certolizumab聚乙二醇在克罗恩病的治疗。

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摘要

The introduction of antibodies directed against tumour necrosis factor (anti-TNF) has dramatically changed the concept of treating patients with Crohn's disease (CD). Unfortunately, the long-term efficacy of anti-TNF agents may be hampered by immunogenicity. The availability of more anti-TNF agents in the therapeutic armamentarium would therefore be of great benefit in patients loosing response to another anti-TNF. In this review, the authors will focus on the efficacy of certolizumab pegol (CZP). AREAS COVERED: A literature search to January 2013 was performed to identify all trials studying CZP in patients with CD. The authors first focused on the mechanism of action of CZP. Second, they evaluated the efficacy of an induction and maintenance therapy with CZP and the impact of CZP on mucosal healing and fistula closure. Next, they explored the influence of previous anti-TNF exposure and baseline C-reactive protein levels. Finally, they analysed the safety data on CZP, including the development of antibodies against CZP and the use of CZP during pregnancy. EXPERT OPINION: Based on the provided literature, CZP could be a good alternative in patients with moderate-to-severe CD failing another anti-TNF agent. More data are required to conclude on its impact on the long-term outcome of CD.
机译：针对肿瘤坏死因子（anti-TNF）的抗体的引入极大地改变了治疗克罗恩氏病（CD）患者的观念。不幸的是，抗TNF药物的长期疗效可能会因免疫原性而受到阻碍。因此，对于失去对另一种抗TNF的反应的患者，治疗性武器库中更多抗TNF药物的可用性将大有裨益。在这篇综述中，作者将专注于certolizumab聚乙二醇（CZP）的功效。覆盖的领域：截至2013年1月进行了文献检索，以鉴定所有研究CD患者中CZP的试验。作者首先关注CZP的作用机制。其次，他们评估了CZP诱导和维持疗法的疗效以及CZP对粘膜愈合和瘘管闭合的影响。接下来，他们探索了先前抗TNF暴露和基线C反应蛋白水平的影响。最后，他们分析了有关CZP的安全性数据，包括抗CZP抗体的开发以及怀孕期间使用CZP的情况。专家意见：根据提供的文献，对于中度至重度CD未能使用另一种抗TNF药物的患者，CZP可能是一个很好的选择。需要更多的数据来总结其对CD长期结果的影响。

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