Room for more IL-6 blockade? Sarilumab for the treatment of rheumatoid arthritis

June Rayford R.; Olsen Nancy J.

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Room for more IL-6 blockade? Sarilumab for the treatment of rheumatoid arthritis

机译：还有更多的IL-6封锁空间吗？沙利鲁单抗治疗类风湿关节炎

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Introduction: Rheumatoid arthritis (RA) treatment has been revolutionized by the development of highly efficacious biotherapeutics. However, a significant subset of RA patients has persistently active disease and ongoing erosive joint damage despite the available therapies. Sarilumab targets interleukin-6, one of the main cytokines mediating inflammation in RA. Positive results with sarilumab in RA clinical trials support the licensing application currently under review with the US Food and Drug Administration.

机译：简介：类风湿关节炎（RA）的治疗已因高效生物疗法的发展而发生了革命性变化。然而，尽管有可用的治疗方法，仍有很大一部分RA患者患有持续活动性疾病和持续性糜烂性关节损伤。 Sarilumab靶向白介素6，白介素6是介导RA炎症的主要细胞因子之一。 sarilumab在RA临床试验中的阳性结果支持目前正在美国食品和药物管理局审查的许可申请。

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《Expert opinion on biological therapy》 |2016年第10期|共7页
作者
June Rayford R.; Olsen Nancy J.;
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原文格式 PDF
正文语种 eng
中图分类治疗学;
关键词
Rheumatoid arthritis; interleukin-6; monoclonal antibody; Sarilumab; Tocilizumab;

机译：类风湿关节炎;白介素-6;单克隆抗体;Sarilumab;Tocilizumab;

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专利

1. Room for more IL-6 blockade? Sarilumab for the treatment of rheumatoid arthritis [J] . June Rayford R., Olsen Nancy J. Expert opinion on biological therapy . 2016,第10期

机译：还有更多的IL-6封锁空间吗？沙利鲁单抗治疗类风湿关节炎
2. Il-6 Involvement in pain, fatigue and mood disorders in rheumatoid arthritis and the effects of Il-6 inhibitor sarilumab [J] . Atzeni Fabiola, Nucera Valeria, Masala Ignazio Francesco, Pharmacological research: The official journal of The Italian Pharmacological Society . 2019,第期

机译：IL-6参与风湿性关节炎的疼痛，疲劳和情绪障碍和IL-6抑制剂Sarilumab的影响
3. A Physiologically Based Pharmacokinetic (PBPK) Model to Predict Disease-Mediated Therapeutic Protein-Drug Interactions Between an Anti-Interleukin-6 (IL-6) Monoclonal Antibody (Sarilumab) and Multiple Cytochrome P450 (CYP) Substrates in Patients with Rheumatoid Arthritis (RA) [J] . Xu Christine R., Paccaly Anne, Kanamaluru Vanaja Journal of pharmacokinetics and pharmacodynamics . 2018,第Suppla期

机译：一种基于生理学的药代动力学（PBPK）模型，以预测抗白细胞介素-6（IL-6）单克隆抗体（Sarilumab）与类风湿性关节炎患者抗白细胞介素-6（IL-6）单克隆抗体（Sarilumab）和多种细胞色素P450（CYP）底物之间的疾病介导的治疗蛋白 - 药物相互作用（RA 的）
4. Development of an AffiMab Engineered to Simultaneously Target IL-6 and TNF for Therapeutic Use in Rheumatoid Arthritis [C] . Bong-Kook Ko, Kyu-Tae Kim, Jong-Ho Lee, PEGS . 2015

机译：在类风湿性关节炎中，设计成同时靶向IL-6和TNF的AICIDAB，用于治疗用途
5. Comparison of the Therapeutic Efficacy of Rheumatoid Arthritis Treatments [D] . Davis, Kacy. 2021

机译：类风湿性关节炎治疗治疗疗效的比较
6. Clinical evaluation of the safety efficacy and tolerability of sarilumab in the treatment of moderate to severe rheumatoid arthritis [O] . Eleftherios Pelechas, Paraskevi V Voulgari, Alexandros A Drosos 2019

机译：沙利鲁单抗治疗中度至重度类风湿关节炎的安全性疗效和耐受性的临床评价
7. Room for more IL-6 blockade? Sarilumab for the treatment of rheumatoid arthritis [O] . Rayford R. June, Nancy J. Olsen 2016

机译：房间有更多的IL-6封锁？ Sarilumab用于治疗类风湿性关节炎

Room for more IL-6 blockade? Sarilumab for the treatment of rheumatoid arthritis

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