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首页> 外文期刊>Expert opinion on biological therapy >Stem cell mobilisation for myocardial repair.
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Stem cell mobilisation for myocardial repair.

机译：干细胞动员用于心肌修复。

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BACKGROUND: The idea that autologous bone marrow derived stem cells (BMCs) can transdifferentiate into cardiomyocytes or vascular cells has been challenged in several scientific reports. OBJECTIVE/METHODS: This review summarises conditions for stem cell mobilisation, their use for therapeutic approaches to prevent ischaemic cardiomyopathy after acute myocardial infarction and current clinical trials. Mechanisms for mobilisation and homing of BMCs are discussed. RESULTS/CONCLUSIONS: The improvement in cardiac function after migration of autologous BMCs to the heart can be explained by their paracrine effects, inducing angiogenesis and preventing ischaemic myocardium from apoptosis. These effects may explain why the number of circulating BMCs is directly correlated with cardiovascular risk and life expectancy. Exercise and hormones are physiological stimuli for the mobilisation of BMCs, whereas cardiovascular risk factors severely reduce their number and functions. Current cardiovascular medications increase the amounts of autologous BMCs.
机译：背景：自体骨髓衍生干细胞（BMC）可以分化为心肌细胞或血管细胞的想法已在一些科学报告中受到质疑。目的/方法：本综述总结了干细胞动员的条件，其在预防急性心肌梗塞后预防缺血性心肌病的治疗方法中的应用以及当前的临床试验。讨论了动员和归巢BMC的机制。结果/结论：自体BMCs迁移至心脏后，其心脏功能的改善可以通过其旁分泌作用，诱导血管生成和防止缺血性心肌细胞凋亡来解释。这些影响可以解释为什么循环中的BMC的数量与心血管疾病的风险和预期寿命直接相关。运动和激素是BMC动员的生理刺激，而心血管危险因素会严重降低其数量和功能。当前的心血管药物增加了自体BMC的数量。

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