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首页> 外文期刊>Expert opinion on biological therapy >Update on the effects of treatment with recombinant tissue-type plasminogen activator (rt-PA) in acute ischemic stroke
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Update on the effects of treatment with recombinant tissue-type plasminogen activator (rt-PA) in acute ischemic stroke

机译：重组组织型纤溶酶原激活剂（rt-PA）治疗急性缺血性中风的最新疗效

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Introduction: Acute ischemic stroke (AIS) represents a major cause of death and disability all over the world. The recommended therapy aims at dissolving the clot to re-establish quickly the blood flow to the brain and reduce neuronal injury. Intravenous administration of recombinant tissue-type plasminogen activator (rt-PA) is clinically used with this goal.Areas covered: A description of beneficial and detrimental effects of rt-PA treatment is addressed. An overview of new therapies against AIS, such as new thrombolytics, sonolysis and sonothrombolysis, endovascular procedures, and association therapies is provided. Updates on the pathophysiological process leading to intracranial hemorrhage (ICH) is also discussed.Expert opinion: rt-PA treatment in AIS patients is beneficial to recovery outcomes. To weaken risks and improve benefits, it might be relevant to consider: i) a definitive identification of risk factors for symptomatic ICH; ii). a better organization of the health care system to reduce time-to-treatment and enhance discharge management. The pharmacological improvement of new thrombolytic drugs (such as tenecteplase and desmoteplase) targeting harmful and maximally exploiting beneficial effects might further reduce mortality and disability in AIS.
机译：简介：急性缺血性中风（AIS）是全世界死亡和致残的主要原因。推荐的治疗方法旨在溶解血块，以快速重建流向大脑的血液并减少神经元损伤。静脉内施用重组组织型纤溶酶原激活剂（rt-PA）达到了这一目标。临床研究领域涉及：描述了rt-PA治疗的有益和有害作用。提供了针对AIS的新疗法的概述，例如新的溶栓剂，声波溶解和声纳血栓溶解，血管内手术以及联合疗法。还讨论了导致颅内出血（ICH）的病理生理过程的最新进展。专家意见：rt-PA治疗AIS患者有助于恢复结果。为了降低风险并提高收益，可能需要考虑以下因素：i）明确确定症状性ICH的危险因素; ii）。更好地组织医疗保健系统，以减少治疗时间并加强出院管理。针对有害和最大程度发挥有益作用的新溶栓药（如替奈普酶和去氨普酶）的药理学改进可能会进一步降低AIS的死亡率和致残率。

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