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Future of tissue engineering in rheumatic diseases.

机译:风湿性疾病组织工程的未来。

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摘要

Chronic inflammation during rheumatoid arthritis and degenerative processes during osteoarthritis eventually result in joint destruction. Anti-inflammatory therapies facilitate the inhibition or delay of progressing joint cartilage and bone loss, but do not regenerate these tissues. Surgical procedures are quite unsatisfactory in long-term evaluation and often lead to endoprothetic joint replacement. Present tissue engineering technologies offer new strategies for the treatment of cartilage and bone defects. Here, beyond implantation of cell suspensions, biomaterials combined with tissue-specific cells or mesenchymal stem cells are clinically applied. This review focuses on state-of-the-art and future in situ mesenchymal stem cell-based tissue engineering approaches for joint repair in patients with rheumatic diseases.
机译:类风湿关节炎的慢性炎症和骨关节炎的退化过程最终导致关节破坏。抗炎疗法有助于抑制或延缓关节软骨和骨质流失,但不会使这些组织再生。手术程序在长期评估中不能令人满意,并且常常导致人工关节置换。当前的组织工程技术为软骨和骨缺损的治疗提供了新的策略。在这里,除了植入细胞悬液外,还结合了与组织特异性细胞或间充质干细胞结合的生物材料。这篇综述着重于风湿性疾病患者关节修复的最新技术和未来基于原位间充质干细胞的组织工程方法。

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