The effect of linkage on limits to artificial selectio

W. G. HILL; ALAN ROBERTSON

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The effect of linkage on limits to artificial selectio

机译：链接对人工选择限制的影响

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A theory of limits to artificial selection in small populations was given by Robertson (1960) in terms of single genes, and. was extended to selection for a quantitative character governed by many loci by ignoring linkage and epistatic interactions between loci. In this paper we include the effect of linkage in a very simple situation, that of two additive loci, though it is hoped to deal with more complex models in further papers. No general algebraic solution to this problem has been found, so that most of Our information has come from Monte Carlo simulation on computers. When there is no recombination between the two loci, an algebraic treatment has been developed which will be described in a later paper.

机译：Robertson（1960）根据单个基因给出了一种在小种群中进行人工选择的限制理论。通过忽略基因座之间的连锁和上位相互作用，扩展到了由许多基因座控制的定量特征的选择。尽管希望在以后的文章中处理更复杂的模型，但在本文中，我们包括了在非常简单的情况下（两个加法基因座）的连锁作用。尚未找到解决该问题的通用代数解决方案，因此我们的大多数信息都来自计算机上的蒙特卡洛模拟。当两个基因座之间没有重组时，将发展代数处理，这将在以后的论文中进行介绍。

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《Genetical Research》 |2007年第6期|共26页
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W. G. HILL; ALAN ROBERTSON;
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5. Technological moral proxies and the ethical limits of automating decision-making in robotics and artificial intelligence. [D] . Millar, Jason L. 2015

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6. Incorporating prior biological information in linkage studies increases power and limits multiple testing [O] . Francesca Lantieri, Halfdan Rydbeck, Paola Griseri, 2007

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7. The Response to Artificial Selection Due to Autosomal Genes of Large Effect II. The Effects of Linkage on Limits to Selection in Finite Populations [O] . BDH Latter 1965

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8. Human chromosome 21: Linkage mapping and cloning in yeast artificial chromosomes. Progress report. [R] . Antonarakis, S. E. 1991

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The effect of linkage on limits to artificial selectio

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