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首页> 外文期刊>Genes, brain, and behavior >The utility of the non-human primate; model for studying gene by environment interactions in behavioral research.
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The utility of the non-human primate; model for studying gene by environment interactions in behavioral research.

机译：非人类灵长类动物的效用;在行为研究中通过环境相互作用研究基因的模型。

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Variation in the serotonin transporter gene-linked polymorphic region (5-HTTLPR) has been associated with anxiety and harm avoidance and is weakly associated with a number of neuropsychiatric disorders, including Type II alcoholism, which has a high rate of comorbidity with antisocial personality disorder. Studies have also demonstrated interactions between 5-HTLPR variation and environmental stress on the incidence of depression. As in humans, there is a serotonin transporter gene promoter length polymorphism in rhesus macaques that produces similar decreases in transcriptional efficiency. Macaques with histories of early-life stress have been shown to exhibit impulsive aggression, incompetent social behavior and increased behavioral and endocrine responsivity to stress. In this paper, we review studies performed previously in our lab and present preliminary data examininng interactions between early rearing and serotonin transporter gene promoter variation on the incidences of play behavior and aggression in infant rhesus macaques. The data presented here highlight the importance of considering gene-environment interactions when studying childhood risk factors for aggression, anxiety and related neuropsychiatric disorders and support the use of the nonhuman primate for studing gene by environment interactions in behavioral research.
机译：血清素转运蛋白基因相关多态性区域（5-HTTLPR）的变异与焦虑和避免伤害有关，并且与许多神经精神疾病（包括II型酒精中毒）弱相关，II型酒精中毒与反社会人格障碍合并症的发生率很高。研究还证明了5-HTLPR变异与环境压力对抑郁症发病率的相互作用。与人类一样，恒河猴中存在5-羟色胺转运蛋白基因启动子长度多态性，导致转录效率下降。猕猴具有较早的生活压力史，已显示出冲动的攻击性，无能的社交行为以及对压力的行为和内分泌反应性增强。在本文中，我们回顾了之前在实验室中进行的研究，并提供了初步的数据来检验早期饲养和血清素转运蛋白基因启动子变异对婴儿恒河猴的游乐行为和攻击行为的相互作用。此处提供的数据突出了研究儿童侵略性，焦虑症和相关神经精神疾病的危险因素时考虑基因与环境相互作用的重要性，并支持在行为研究中利用非人类灵长类动物通过环境相互作用研究基因。

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