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首页> 外文期刊>International review of cell and molecular biology >Cell and molecular biology of the novel protein tyrosine-phosphatase-interacting protein 51.
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Cell and molecular biology of the novel protein tyrosine-phosphatase-interacting protein 51.

机译：新型蛋白质酪氨酸磷酸酶相互作用蛋白51的细胞和分子生物学。

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摘要

This chapter examines the current state of knowledge about the expression profile, as well as biochemical properties and biological functions of the evolutionarily conserved protein PTPIP51. PTPIP51 is apparently expressed in splice variants and shows a particularly high expression in epithelia, skeletal muscle, placenta, and germ cells, as well as during mammalian development and in cancer. PTPIP51 is an in vitro substrate of Src- and protein kinase A, the PTP1B/TCPTP protein tyrosine phosphatases and interacts with 14-3-3 proteins, the Nuf2 kinetochore protein, the ninein-interacting CGI-99 protein, diacylglycerol kinase alpha, and also with itself forming dimers and trimers. Although the precise cellular function remains to be elucidated, the current data implicate PTPIP51 in signaling cascades mediating proliferation, differentiation, apoptosis, and motility.
机译：本章介绍了有关表达谱以及进化上保守的蛋白PTPIP51的生化特性和生物学功能的最新知识。 PTPIP51显然在剪接变体中表达，并在上皮，骨骼肌，胎盘和生殖细胞中以及在哺乳动物发育和癌症中表现出特别高的表达。 PTPIP51是Src和蛋白激酶A，PTP1B / TCPTP蛋白酪氨酸磷酸酶的体外底物，并与14-3-3蛋白，Nuf2线粒体蛋白，与Ninin相互作用的CGI-99蛋白，二酰基甘油激酶α和也可以自身形成二聚体和三聚体。尽管确切的细胞功能尚待阐明，但目前的数据暗示PTPIP51参与介导增殖，分化，凋亡和运动性的信号级联反应。

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