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首页> 外文期刊>Genomics >Atp10a, the mouse ortholog of the human imprinted ATP10A gene, escapes genomic imprinting.
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Atp10a, the mouse ortholog of the human imprinted ATP10A gene, escapes genomic imprinting.

机译：Atp10a是人类印迹的ATP10A基因的小鼠直系同源基因，可逃脱基因组印迹。

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The mouse Atp10a gene is located at the border of an imprinted domain distal to the p-locus on mouse chromosome 7. The localization of Atp10a neighboring the maternally expressed gene Ube3a in the imprinted domain and an unusual inheritance pattern of the obesity phenotype with a p-locus deletion have suggested that Atp10a might be imprinted and associated with body fat. Recently, its human ortholog, ATP10A, was identified as the second imprinted gene with maternal expression in the human chromosome 15q11-q13 imprinted domain. To elucidate the imprinting status of Atp10a, we performed expression analysis in various tissues from reciprocal crosses between C57BL/6 and PWK (divergent strains of Mus musculus) mice. The results revealed that Atp10a was biallelically expressed in all tissues examined. Furthermore, there was no differential methylation in the CpG island and no antisense transcripts of the gene. These findings suggest that the mouse Atp10a gene escapes genomic imprinting.
机译：小鼠Atp10a基因位于小鼠染色体7上p位点远侧的印迹结构域的边界处。与母本表达的基因Ube3a相邻的Atp10a在印迹结构域中的定位以及肥胖表型与p的异常继承模式-基因座缺失提示Atp10a可能被烙印并与体内脂肪相关。最近，它的人类直系同源物ATP10A被鉴定为在人染色体15q11-q13印迹域中具有母体表达的第二个印迹基因。为了阐明Atp10a的印迹状态，我们从C57BL / 6和PWK（小家鼠不同株）小鼠的相互杂交中在各种组织中进行了表达分析。结果显示，Atp10a在所有检查的组织中均双等位基因表达。此外，在CpG岛中没有差异甲基化，并且该基因没有反义转录物。这些发现表明，小鼠Atp10a基因逃脱了基因组印迹。

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