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首页> 外文期刊>Genomics >A review and comparison of the murine alpha(1)-antitrypsin and alpha(1)-antichymotrypsin multigene clusters with the human clade A serpins.
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A review and comparison of the murine alpha(1)-antitrypsin and alpha(1)-antichymotrypsin multigene clusters with the human clade A serpins.

机译：审查和比较与人类进化枝A Serpins的鼠α（1）-抗胰蛋白酶和α（1）-抗胰凝乳蛋白酶多基因簇。

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摘要

The major human plasma protease inhibitors, alpha(1)-antitrypsin and alpha(1)-antichymotrypsin, are each encoded by a single gene, whereas in the mouse they are represented by clusters of 5 and 14 genes, respectively. Although there is a high degree of overall sequence similarity within these groupings, the reactive-center loop (RCL) domain, which determines target protease specificity, is markedly divergent. The literature dealing with members of these mouse serine protease inhibitor (serpin) clusters has been complicated by inconsistent nomenclature. Furthermore, some investigators, unaware of the complexity of the family, have failed to distinguish between closely related genes when measuring expression levels or functional activity. We have reviewed the literature dealing with the mouse equivalents of human alpha(1)-antitrypsin and alpha(1)-antichymotrypsin and made use of the recently completed mouse genome sequence to propose a systematic nomenclature. We have also examined the extended mouse clade "a" serpin cluster at chromosome 12F1 and compared it with the syntenic region at human chromosome 14q32. In summarizing the literature and suggesting a standardized nomenclature, we aim to provide a logical structure on which future research may be based.
机译：主要的人类血浆蛋白酶抑制剂，α（1）-抗胰蛋白酶和α（1）-抗胰凝乳蛋白酶，均由单个基因编码，而在小鼠中，它们分别由5和14个基因簇组成。尽管在这些组中具有高度的整体序列相似性，但决定靶蛋白酶特异性的反应中心环（RCL）域却明显不同。有关这些小鼠丝氨酸蛋白酶抑制剂（丝氨酸蛋白酶抑制剂）簇成员的文献因术语不一致而变得复杂。此外，一些研究者不了解该家族的复杂性，在测量表达水平或功能活性时未能区分密切相关的基因。我们已经审查了有关人类α（1）-抗胰蛋白酶和α（1）-抗胰凝乳蛋白酶的小鼠等效物的文献，并利用了最近完成的小鼠基因组序列来提出系统的命名法。我们还检查了在12F1染色体上延伸的小鼠进化枝“ a”丝氨酸蛋白酶抑制剂簇，并将其与人类14q32染色体的同义区域进行了比较。在总结文献并提出标准化术语时，我们旨在提供一个可以作为未来研究基础的逻辑结构。

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