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首页> 外文期刊>Genomics >Methylation dynamics of repetitive DNA elements in the mouse germ cell lineage.
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Methylation dynamics of repetitive DNA elements in the mouse germ cell lineage.

机译：小鼠生殖细胞谱系中重复性DNA元素的甲基化动力学。

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Repetitive DNA elements account for a substantial fraction of the mammalian genome. Many are subject to DNA methylation, which is known to undergo dynamic change during mouse germ cell development. We found that repeat sequences of three different classes retain high levels of methylation at E12.5, when methylation is erased from many single-copy genes. Maximal demethylation of repeats was seen later in development and at different times in male and female germ cells. At none of the time points examined (E12.5, E15.5, and E17.5) did we see complete demethylation, suggesting that methylation patterns on repeats may be passed on from one generation to the next. In male germ cells, we observed a de novo methylation event resulting in complete methylation of all the repeats in the interval between E15.5 and E17.5, which was not seen in females. These results suggest that repeat sequences undergo coordinate changes in methylation during germ cell development and give further insights into germ cell reprogramming in mice.
机译：重复的DNA元件占哺乳动物基因组的很大一部分。许多细胞都经历了DNA甲基化，这已知在小鼠生殖细胞发育过程中会发生动态变化。我们发现，当从许多单拷贝基因中删除甲基化时，三种不同类别的重复序列在E12.5处保留高水平的甲基化。在雄性和雌性生殖细胞的发育后期和不同时间观察到重复序列的最大去甲基化。在所检查的任何时间点（E12.5，E15.5和E17.5）都没有看到完全脱甲基，这表明重复序列上的甲基化模式可能会一代一代地传递给下一代。在雄性生殖细胞中，我们观察到从头甲基化事件，导致在E15.5和E17.5之间的间隔中所有重复序列完全甲基化，这在雌性中未见。这些结果表明，重复序列在生殖细胞发育过程中经历甲基化的协调变化，并为小鼠生殖细胞的重新编程提供了进一步的见识。

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