Estimating genotyping error rates from Mendelian errors in SNP array genotypes and their impact on inference.

Saunders IW; Brohede J; Hannan GN

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Estimating genotyping error rates from Mendelian errors in SNP array genotypes and their impact on inference.

机译：从SNP阵列基因型中的孟德尔错误估计基因分型错误率及其对推断的影响。

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A simple method of inferring the genotyping error rate of SNP arrays and similar high-throughput genotyping methods from Mendelian errors is described. Application to genotypes from small families using the Affymetrix GeneChip Human Mapping 50 k Array indicates an error rate of about 0.1%, and this rate can be reduced by increasing the quality criterion for calls, though at the cost of a reduced genotype call rate, which limits the benefit available. Simulated data are used to show that the number of SNPs on this array is sufficient for such a low error rate to have little impact on identical by descent-based inference for disease linkage in sib-pair studies.

机译：描述了一种从孟德尔误差中推断SNP阵列基因分型错误率的简单方法以及类似的高通量基因分型方法。使用Affymetrix GeneChip Human Mapping 50 k阵列应用于小型家族的基因型时，错误率约为0.1％，可以通过提高通话质量标准来降低该错误率，尽管这样做的代价是降低了基因型的通话率。限制了可用利益。模拟数据用于显示该阵列上SNP的数量足以使如此低的错误率对基于同胞对研究的疾病连锁基于血统的推断几乎没有影响。

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《Genomics》 |2007年第3期|共6页
作者
Saunders IW; Brohede J; Hannan GN;
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正文语种 eng
中图分类遗传学;
关键词
Algorithms; Australia; Family Health; Genetic Screening; Genetic Techniques; 算法; 澳大利亚; 家庭卫生; 遗传筛选; 遗传学技术; 基因组; 基因组; 人; 基因型;

机译：Algorithms;Australia;Family Health;Genetic Screening;Genetic Techniques;算法;澳大利亚;家庭卫生;遗传筛选;遗传学技术;基因组;基因组;人;基因型;

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1. Estimating genotyping error rates from Mendelian errors in SNP array genotypes and their impact on inference. [J] . Saunders IW, Brohede J, Hannan GN Genomics . 2007,第3期

机译：从SNP阵列基因型中的孟德尔错误估计基因分型错误率及其对推断的影响。
2. ConGenR: rapid determination of consensus genotypes and estimates of genotyping errors from replicated genetic samples [J] . Lonsinger Robert C., Waits Lisette P. Conservation Genetics Resources . 2015,第4期

机译：ConGenR：快速确定共有基因型并从复制的遗传样本中估算基因分型错误
3. Collapsing SNP Genotypes in Case-Control Genome-Wide Association Studies Increases the Type I Error Rate and Power [J] . Abigail G. Matthewsu0003 Chad Haynes†Chang Liu‡ Jurg Ottu0003u0003 Statistical Applications in Genetics and Molecular Biology . 2008,第1期

机译：在病例对照基因组-全基因组关联研究中，折叠的SNP基因型增加了I型错误率和功效
4. TRADEOFF BETWEEN NO-CALL REDUCTION IN GENOTYPING ERROR RATE AND LOSS OF SAMPLE SIZE FOR GENETIC CASE/CONTROL ASSOCIATION STUDIES [C] . S. J. KANG, D. GORDON, A. M. BROWN, Pacific Symposium on Biocomputing 2004; Jan 6-10, 2004; Hawaii, USA . 2004

机译：遗传案例/控制关联研究中基因型错误率的无电话减少和样本大小的损失之间的权衡
5. The effects of errors in the specification of genotype of a single nucleotide polymorphism (SNP) on the chi-squared test of association between disease and SNP type. [D] . Kang, Sun Jung. 2003

机译：单核苷酸多态性（SNP）基因型规范中的错误对疾病与SNP类型之间关联性的卡方检验的影响。
6. Estimating autozygosity from high-throughput information: effects of SNP density and genotyping errors [O] . Maja Ferenčaković, Johann Sölkner, Ino Curik 2013

机译：从高通量信息估计自噬：SNP密度和基因分型错误的影响
7. Estimating genotyping error rates from Mendelian errors in SNP array genotypes and their impact on inference [O] . Saunders Ian W., Brohede Jesper, Hannan Garry N. 2007

机译：从SNP阵列基因型中的孟德尔误差估计基因分型错误率及其对推断的影响

Estimating genotyping error rates from Mendelian errors in SNP array genotypes and their impact on inference.

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