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首页> 外文期刊>Genomics >Genomic differences between type strain PG1 and field strains of Mycoplasma mycoides subsp. mycoides small-colony type.
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Genomic differences between type strain PG1 and field strains of Mycoplasma mycoides subsp. mycoides small-colony type.

机译：PG1型菌株与支原体支原体亚种的田间菌株之间的基因组差异。霉菌小菌落型。

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摘要

The recently accomplished complete genomic sequence analysis of the type strain PG1 of Mycoplasma mycoides subsp. mycoides small-colony type revealed four large repeated segments of 24, 13, 12, and 8 kb that are flanked by insertion sequence (IS) elements. Genetic analysis of type strain PG1 and African, European, and Australian field and vaccine strains revealed that the 24-kb genetic locus is repeated only in PG1 and not in other M. mycoides subsp. mycoides SC strains. In contrast, the 13-kb genetic locus was found duplicated in some strains originating from Africa and Australia but not in strains that were isolated from the European outbreaks. The 12- and 8-kb genetic loci were found in two and three copies, respectively, in all 28 strains analyzed. The flanking IS elements are assumed to lead to these tandem duplications, thus contributing to genomic plasticity. This aspect must be considered when designing novel diagnostic approaches and recombinant vaccines.
机译：最近完成的支原体支原体亚种PG1型菌株的完整基因组序列分析。真菌病小菌落类型揭示了四个大的重复片段，分别为24、13、12和8 kb，两侧是插入序列（IS）元素。对PG1型菌株以及非洲，欧洲和澳大利亚的田间和疫苗菌株的遗传分析表明，仅在PG1中重复了24-kb的遗传基因座，而在其他M. mycoides亚种中则没有。杀真菌剂SC菌株。相比之下，发现13 kb的遗传基因座在某些源自非洲和澳大利亚的菌株中重复，但在从欧洲疫情中分离出的菌株中却没有。在所分析的所有28个菌株中，分别以2个和3个拷贝发现了12和8 kb的基因座。侧翼的IS元素被认为会导致这些串联重复，从而有助于基因组可塑性。设计新颖的诊断方法和重组疫苗时必须考虑这一方面。

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