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The Wasp System: An open source environment for managing and analyzing genomic data

机译：Wasp System：用于管理和分析基因组数据的开源环境

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摘要

The challenges associated with the management, analysis and interpretation of assays based on massively-parallel sequencing (MPS) are both individually complex and numerous. We describe what we believe to be the appropriate solution, one that represents a departure from traditional computational biology approaches. The Wasp System is an open source, distributed package written in Spring/J2EE that creates a foundation for development of an end-to-end solution for MPS-based experiments or clinical tests. Recognizing that one group will be unable to solve these challenges in isolation, we describe a nurtured open source development model that will allow the software to be collectively used, shared and developed. The ultimate goal is to emulate resources such as the Virtual Observatory of the astrophysics community, enabling computationally-inexpert scientists and clinicians to explore and interpret their MPS data. Here we describe the current implementation and development of the Wasp System and the roadmap for its community development.
机译：与基于大规模平行测序（MPS）的检测的管理，分析和解释相关的挑战既复杂又众多。我们描述了我们认为合适的解决方案，它代表了与传统计算生物学方法的不同。 Wasp System是用Spring / J2EE编写的开源分布式软件包，为开发基于MPS的实验或临床测试的端到端解决方案奠定了基础。认识到一个团队将无法孤立地解决这些挑战，我们描述了一种经过培育的开源开发模型，该模型将允许软件被集体使用，共享和开发。最终目标是模拟诸如天体物理学社区的虚拟天文台之类的资源，从而使计算不熟练的科学家和临床医生能够探索和解释其MPS数据。在这里，我们描述了Wasp System的当前实施和开发以及其社区发展的路线图。

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