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The genetic equidistance phenomenon at the proteomic level

机译：蛋白质组学水平的遗传等距现象

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The field of molecular evolution started with the alignment of a few protein sequences in the early 1960s. Among the first results found, the genetic equidistance result has turned out to be the most unexpected. It directly inspired the ad hoc universal molecular clock hypothesis that in turn inspired the neutral theory. Unfortunately, however, what is only a maximum distance phenomenon was mistakenly transformed into a mutation rate phenomenon and became known as such. Previous work studied a small set of selected proteins. We have performed proteome wide studies of 7 different sets of proteomes involving a total of 15 species. All 7 sets showed that within each set of 3 species the least complex species is approximately equidistant in average proteome wide identity to the two more complex ones. Thus, the genetic equidistance result is a universal phenomenon of maximum distance. There is a reality of constant albeit stepwise or discontinuous increase in complexity during evolution, the rate of which is what the original molecular clock hypothesis is really about. These results provide additional lines of evidence for the recently proposed maximum genetic diversity (MGD) hypothesis. (C) 2016 Elsevier Inc. All rights reserved.
机译：分子进化的领域始于1960年代初期一些蛋白质序列的比对。在最初发现的结果中，遗传等距结果被证明是最出乎意料的。它直接启发了特殊的通用分子钟假说，反过来又激发了中性理论。然而，不幸的是，仅是最大距离现象被错误地转换为突变率现象，并因此而闻名。先前的工作研究了一小组选定的蛋白质。我们已经对7种不同的蛋白质组进行了蛋白质组范围的研究，涉及总共15种。所有7个样本集都表明，在3个物种的集合中，最不复杂的物种在平均蛋白质组宽度同一性上与两个更复杂的物种大约等距。因此，遗传等距结果是最大距离的普遍现象。尽管进化过程​​中复杂性呈逐步增加或不连续增加的事实，但其速率恰恰是原始分子时钟假设的实质所在。这些结果为最近提出的最大遗传多样性（MGD）假设提供了更多的证据。 （C）2016 Elsevier Inc.保留所有权利。

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