...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Genes and Development: a Journal Devoted to the Molecular Analysis of Gene Expression in Eukaryotes, Prokaryotes, and Viruses >Checkpoint kinases and the INO80 nucleosome remodeling complex enhance global chromatin mobility in response to DNA damage
【24h】

Checkpoint kinases and the INO80 nucleosome remodeling complex enhance global chromatin mobility in response to DNA damage

机译：Checkpoint激酶和INO80核小体重塑复合物可响应DNA损伤而提高整体染色质迁移率

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Double-strand break repair by recombination requires a homology search. In yeast, induced breaks move significantly more than undamaged loci. To examine whether DNA damage provokes an increase in chromatin mobility generally, we tracked undamaged loci under DNA-damaging conditions. We found that the yeast checkpoint factors Mec1, Rad9, and Rad53 are required for genome-wide increases in chromatin mobility, but not the repair protein Rad51. Mec1 activation by targeted Ddc1/Ddc2 enhances chromatin mobility even in the absence of damage. Finally, the INO80 chromatin remodeler is shown to act downstream from Mec1 to increase chromatin mobility, highlighting an additional damage-related role of this nucleosome remodeling complex.
机译：通过重组的双链断裂修复需要同源性搜索。在酵母中，诱发的断裂比未受损的基因座移动得多。为了检查DNA损伤是否通常引起染色质迁移率的增加，我们追踪了在DNA损伤条件下未受损的基因座。我们发现，酵母检查点因子Mec1，Rad9和Rad53是染色质迁移率在全基因组范围内增加所必需的，而修复蛋白Rad51则不是。靶向Ddc1 / Ddc2激活的Mec1即使在没有损伤的情况下也能增强染色质的迁移率。最终，INO80染色质重塑剂显示出在Mec1下游起作用，以增加染色质迁移率，突显了这种核小体重塑复合物的其他损伤相关作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号