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首页> 外文期刊>Gut: Journal of the British Society of Gastroenterology >Association of insulin and insulin-like growth factors with Barrett's oesophagus
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Association of insulin and insulin-like growth factors with Barrett's oesophagus

机译：胰岛素和胰岛素样生长因子与巴雷特食管的关系

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Background: It is postulated that high serum levels of insulin and insulin growth factor 1 (IGF-1) mediate obesity-associated carcinogenesis. The relationship of insulin, IGF-1 and IGF binding proteins (IGFBP) with Barrett's oesophagus (BO) has not been well examined. Methods: Serum levels of insulin and IGFBPs in patients with BO were compared with two separate control groups: subjects with gastro-oesophageal reflux disease (GORD) and screening colonoscopy controls. Fasting insulin, IGF-1 and IGFBPs were assayed in the serum of BO cases (n=135), GORD (n=135) and screening colonoscopy (n=932) controls recruited prospectively at two academic hospitals. Logistic regression was used to estimate the risk of BO. Results: Patients in the highest tertile of serum insulin levels had an increased risk of BO compared with colonoscopy controls (adjusted OR 2.02, 95% CI 1.15 to 3.54) but not compared with GORD controls (adjusted OR 1.55, 95% CI 0.76 to 3.15). Serum IGF-1 levels in the highest tertile were associated with an increased risk of BO (adjusted OR 4.05, 95% CI 2.01 to 8.17) compared with the screening colonoscopy control group but were not significantly different from the GORD control group (adjusted OR 0.57, 95% CI 0.27 to 1.17). IGFBP-1 levels in the highest tertile were inversely associated with a risk of BO in comparison with the screening colonoscopy controls (adjusted OR 0.11, 95% CI 0.05 to 0.24) but were not significantly different from the GORD control group (adjusted OR 1.04, 95% CI 0.49 to 2.16). IGFBP-3 levels in the highest tertile were inversely associated with the risk of BO compared with the GORD controls (OR 0.36, 95% CI 0.16 to 0.81) and also when compared with the colonoscopy controls (OR 0.40, 95% CI 0.20 to 0.79). Conclusions: These results provide support for the hypothesis that the insulin/IGF signalling pathways have a role in the development of BO.
机译：背景：据推测，高血清胰岛素水平和胰岛素生长因子1（IGF-1）介导肥胖相关的致癌作用。胰岛素，IGF-1和IGF结合蛋白（IGFBP）与Barrett食道（BO）的关系尚未得到很好的检查。方法：将BO患者的血清胰岛素和IGFBPs水平与两个单独的对照组进行比较：胃食管反流病（GORD）受试者和结肠镜检查对照组。空腹胰岛素，IGF-1和IGFBPs在BO病例（n = 135），GORD（n = 135）和结肠镜检查（n = 932）的血清中进行了分析，前瞻性招募了两家大学医院。使用逻辑回归来估计BO的风险。结果：与结肠镜检查对照组（校正后的OR 2.02，95％CI 1.15至3.54）相比，血清胰岛素水平最高的患者的BO风险增加，但与GORD对照例（校正后的OR 1.55，95％CI 0.76至3.15）相比，BO发生风险增加）。与筛查结肠镜检查对照组相比，最高三分位数血清IGF-1水平与BO风险增加相关（校正后的OR为4.05，95％CI为2.01至8.17），但与GORD对照组相比无显着差异（校正后的OR为0.57） ，95％CI 0.27至1.17）。与筛查结肠镜检查对照组相比，最高三分位数中的IGFBP-1水平与BO风险呈负相关（调整后的OR为0.11，95％CI为0.05至0.24），但与GORD对照组相比（调整后的OR为1.04， 95％CI 0.49至2.16）。与GORD对照（OR 0.36，95％CI 0.16至0.81）以及结肠镜检查对照（OR 0.40，95％CI 0.20至0.79）相比，最高三分位数中的IGFBP-3水平与BO风险呈负相关。 ）。结论：这些结果为胰岛素/ IGF信号通路在BO发生中起作用的假设提供了支持。

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