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T cell responses in hepatitis C: The good, the bad and the unconventional

机译:丙型肝炎的T细胞反应:好,坏和非常规

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摘要

Over recent years, it has become increasingly accepted that virus-specific CD4+ and CD8+ T cell responses play a major role in outcome and pathogenesis of hepatitis C virus (HCV) infection. Indeed, while the emergence of strong and multispecific T cell responses may correlate with spontaneous viral clearance, the virus has developed several mechanisms to avoid T cell control in the majority of acutely HCV-infected patients that subsequently develop persistent HCV infection. In this review, we will discuss the current knowledge about the role of cellular immune responses in HCV infection. Specifically, we will emphasise recent new insights into the effector functions of T cells, possible mechanisms of their failure and the host - virus interactions occurring at the site of the disease, the liver.
机译:近年来,越来越多的人接受病毒特异性CD4 +和CD8 + T细胞反应在丙型肝炎病毒(HCV)感染的结果和发病机理中起主要作用。确实,尽管强而多特异性T细胞反应的出现可能与病毒的自发清除有关,但该病毒已开发出多种机制来避免大多数急性HCV感染患者的T细胞控制,而这些患者随后发展为持续性HCV感染。在这篇综述中,我们将讨论有关细胞免疫应答在HCV感染中作用的最新知识。具体来说,我们将着重介绍有关T细胞效应子功能,其衰竭的可能机制以及在疾病部位,肝脏发生的宿主-病毒相互作用的最新见解。

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