• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Islets >Morphological assessment of pancreatic islet hormone content following aerobic exercise training in rats with poorly controlled Type 1 diabetes mellitus
【24h】

Morphological assessment of pancreatic islet hormone content following aerobic exercise training in rats with poorly controlled Type 1 diabetes mellitus

机译：有氧运动训练对1型糖尿病控制不良的大鼠胰岛激素含量的形态学评估

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Regular exercise has been shown to improve many complications of Type 1 diabetes mellitus (T1DM) including enhanced glucose tolerance and increased cardiac function. While exercise training has been shown to increase insulin content in pancreatic islets of rats with T1DM, experimental models were severely hyperglycemic and not undergoing insulin treatment. Further, research to date has yet to determine how exercise training alters glucagon content in pancreatic islets. The purpose of the present investigation was to determine the impact of a 10-week aerobic training program on pancreatic islet composition in insulin-treated rats with T1DM. Second, it was determined whether the acute, exercise-mediated reduction in blood glucose experienced in rats with T1DM would become larger in magnitude following aerobic exercise training. Diabetes was induced in male Sprague-Dawley rats by multiple low dose injections of streptozotocin (20mg/kg i.p.) and moderate intensity aerobic exercise training was performed on a motorized treadmill for one hour per day for a total of 10 weeks. Rats with T1DM demonstrated significantly less islet insulin, and significantly more islet glucagon hormone content compared with non-T1DM rats, which did not significantly change following aerobic training. The reduction in blood glucose in response to a single exercise bout was similar across 10 weeks of training. Results also support the view that different subpopulations of islets exist, as small islets (< 50 mu m diameter) had significantly more insulin and glucagon in rats with and without T1DM.
机译：定期运动已显示可改善1型糖尿病（T1DM）的许多并发症，包括增强的糖耐量和增强的心脏功能。尽管运动训练已显示可增加患有T1DM的大鼠胰岛中的胰岛素含量，但实验模型存在严重的高血糖症且未接受胰岛素治疗。此外，迄今为止的研究尚未确定运动​​训练如何改变胰岛中的胰高血糖素含量。本研究的目的是确定为期10周的有氧训练计划对T1DM胰岛素治疗大鼠的胰岛组成的影响。第二，确定在有氧运动训练后，运动介导的T1DM大鼠血糖急性下降是否会变大。通过多次低剂量链脲佐菌素（20mg / kg腹腔注射）在雄性Sprague-Dawley大鼠中诱发糖尿病，每天在电动跑步机上进行中等强度的有氧运动训练，每天进行一小时，共10周。与非T1DM大鼠相比，患有T1DM的大鼠表现出明显更少的胰岛胰岛素和明显更高的胰岛胰高血糖素激素含量，有氧训练后大鼠的胰岛胰高血糖素激素含量没有明显变化。在训练的10周中，因单次运动引起的血糖降低相似。结果还支持以下观点：存在不同的胰岛亚群，因为小胰岛（直径小于50微米）在患有和未患有T1DM的大鼠中具有明显更多的胰岛素和胰高血糖素。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号