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Short and medium chain fatty acids make a comeback

机译：中短链脂肪酸卷土重来

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In vitro work confirms the antimicrobial properties of medium chain fatty acids. Their differential mode of action compared to the better known short chain fatty acids might explain the fact that piglet trials have repeatedly shown synergistic effects of combinations of the two. MCFA appear to be a potent enhancer of the effects of SCFA, even at low inclusion levels. The antimicrobial activity of short (SCFA) and medium chain fatty acids (MCFA) has already been known for many decades. Short chain fatty acids like sorbic, benzoic and propionic acid are used by food technologists as food preservatives (See Kabara, 1993 for an overview). Animal nutritionists also appreciate these and other SCFA as (alternative) growth promoters, feed preservatives and gut stabilisers. The potential of MCFA for these applications has been less thoroughly investigated until recently. Vast developments in the applications of antibiotics and chemo-therapeutics during the 1950s and 1960s stopped any further exploitationof the antimicrobial properties of these fatty acids. However, the ban on the use of certain antibiotics as growth promoters in animal feeds has given rise to renewed research interest in this area. Specifically combinations of SCFA and MCFA have been shown to be of interest as feed supplements.
机译：体外研究证实了中链脂肪酸的抗菌特性。与已知的短链脂肪酸相比，它们的不同作用方式可能解释了这样一个事实，即仔猪试验已经反复证明了两者组合的协同作用。 MCFA似乎是SCFA作用的有效增强剂，即使在低夹杂物含量下也是如此。短链脂肪酸（SCFA）和中链脂肪酸（MCFA）的抗微生物活性已有数十​​年的历史了。食品技术人员使用山梨酸，苯甲酸和丙酸等短链脂肪酸作为食品防腐剂（有关概述，请参见Kabara，1993）。动物营养学家也赞赏这些和其他SCFA作为（替代）生长促进剂，饲料防腐剂和肠道稳定剂。直到最近，尚未对MCFA在这些应用中的潜力进行过彻底的研究。在1950年代和1960年代，抗生素和化学疗法的广泛应用使这些脂肪酸的抗微生物特性无法得到进一步利用。但是，禁止在动物饲料中使用某些抗生素作为生长促进剂，引起了对该领域的新的研究兴趣。已经显示出SCFA和MCFA的特定组合作为饲料补充剂是令人感兴趣的。

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