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首页> 外文期刊>Fertility and Sterility: Official Journal of the American Fertility Society, Pacific Coast Fertility Society, and the Canadian Fertility and Andrology Society >Proportional change of CD4+CD25+ regulatory T cells in decidua and peripheral blood in unexplained recurrent spontaneous abortion patients.
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Proportional change of CD4+CD25+ regulatory T cells in decidua and peripheral blood in unexplained recurrent spontaneous abortion patients.

机译：原因不明的反复自然流产患者蜕膜和外周血CD4 + CD25 +调节性T细胞的比例变化。

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摘要

OBJECTIVE: To investigate the proportional changes of CD4(+)CD25(+) regulatory T cells in peripheral blood and decidua in unexplained recurrent spontaneous abortion (URSA) and normal pregnant (NP) women. DESIGN: Prospective, case-control study. SETTING: Large public hospital in a major city in China. PATIENT(S): Twenty-five URSA patients and 34 normal, early pregnant, control women. INTERVENTION(S): Measurements of CD4(+)CD25(+) regulatory T cells in decidua and peripheral blood. MAIN OUTCOME MEASURE(S): The proportion of CD4(+)CD25(bright) regulatory T cells; the percentage of CD25(bright) cells in the CD4(+) T-cell population. RESULT(S): The proportions of CD4(+)CD25(bright) T cells in both decidua and peripheral blood in URSA patients were statistically significantly lower than those in control women. Meanwhile, the percentage of CD25(bright) cells in the CD4(+) T-cell population in decidua was statistically significantly lower in URSA patients than in control women. The percentage of CD25(bright) cells in the CD4(+) T-cell population in decidua was statistically significantly higher than that in peripheral blood in control women, whereas the difference was not significant in patients who have URSA. CONCLUSION(S): Human CD4(+)CD25(bright) T cells play a major role in tolerating conceptus antigens and therefore may contribute to the maintenance of pregnancy. The data suggest that CD4(+)CD25(+) regulatory T cells may be a novel target in URSA therapy.
机译：目的：探讨原因不明的反复自然流产（URSA）和正常孕妇（NP）妇女外周血和蜕膜中CD4（+）CD25（+）调节性T细胞的比例变化。设计：前瞻性病例对照研究。地点：中国主要城市的大型公立医院。患者：25名URSA患者和34名正常，早期怀孕的对照女性。干预：蜕膜和外周血中CD4（+）CD25（+）调节性T细胞的测量。主要观察指标：CD4（+）CD25（亮）调节性T细胞的比例; CD4（+）T细胞群体中CD25（亮）细胞的百分比。结果：URSA患者蜕膜和外周血中CD4（+）CD25（亮）T细胞的比例在统计学上显着低于对照组妇女。同时，URSA患者蜕膜中CD4（+）T细胞群体中CD25（亮）细胞的百分比在统计学上显着低于对照组女性。蜕膜中CD4（+）T细胞群体中CD25（亮）细胞的百分比在统计学上显着高于对照组妇女的外周血，而在患有URSA的患者中差异不显着。结论：人CD4（+）CD25（亮）T细胞在耐受概念抗原中起主要作用，因此可能有助于维持妊娠。数据表明CD4（+）CD25（+）调节性T细胞可能是URSA治疗中的新靶标。

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