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首页> 外文期刊>Gynecologic Oncology: An International Journal >Comparison of HE4, CA125 and ROMA algorithm in women with a pelvic mass: Correlation with pathological outcome
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Comparison of HE4, CA125 and ROMA algorithm in women with a pelvic mass: Correlation with pathological outcome

机译：女性盆腔肿块中HE4，CA125和ROMA算法的比较：与病理结果的关系

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Objective The quality of first surgery is one of the most important prognostic factors in ovarian cancer patients. Pre-surgical distinction of benign and malignant pelvic mass plays a critical role in ovarian cancer management and survival. The aim of this study was to evaluate the clinical performance of ROMA algorithm and of CA125 and HE4 in the triage of patients with a pelvic mass undergoing surgery, in order to discriminate benign from malignant disease. Methods Three hundred and forty-nine pre- and post-menopausal women, aged 18 years or older undergoing surgery because of a pelvic mass were enrolled: serum concentrations of CA125 and HE4 were determined and ROMA was calculated for each sample. Results Median serum CA125 and HE4 levels were higher in patients with EOC compared to subjects with benign disease (p < 0.0001). The resultant accuracy (using Receiver Operating Characteristics, ROC Area) values for HE4, CA125 and ROMA showed a good performance ranging from 89.8% for CA125 in pre-menopausal patients to 93.3% for ROMA in post-menopausal patients: AUC for ROMA resulted significantly higher in comparison to CA125 alone (93.3% vs 90.3%, p = 0.0018) in post menopausal patients. A sub-analysis considering the 40 patients with endometrioid disease showed the highest accuracy of HE4 in these patients. Conclusions Data presented confirm the accuracy of HE4 and of the ROMA algorithm in the distinction of ovarian carcinoma from benign disease, with a trend towards better performance for ROMA than for CA125 alone, statistically significant in postmenopausal patients.
机译：目的首次手术的质量是卵巢癌患者最重要的预后因素之一。良性和恶性盆腔肿块的术前区别在卵巢癌的治疗和生存中起着至关重要的作用。这项研究的目的是评估ROMA算法以及CA125和HE4在进行手术的盆腔肿块患者分诊中的临床表现，以区分良性与恶性疾病。方法纳入349例因骨盆肿块而接受手术的18岁以上绝经前和绝经后妇女：测定血清CA125和HE4的浓度，并计算每个样品的ROMA。结果EOC患者的血清中CA125和HE4水平高于良性疾病患者（p <0.0001）。结果显示，HE4，CA125和ROMA的准确度（使用接收器工作特性，ROC面积）值显示出良好的性能，从绝经前患者的CA125的89.8％到绝经后患者的ROMA的93.3％：ROMA的AUC显着与绝经后患者中单独的CA125相比更高（93.3％对90.3％，p = 0.0018）。对40名子宫内膜异位疾病患者进行的分项分析显示，这些患者中HE4的准确性最高。结论所提供的数据证实了HE4和ROMA算法在区分卵巢癌与良性疾病方面的准确性，并且与绝经后患者相比，ROMA的性能优于单独的CA125，具有统计学意义。

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