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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Effects of ethinyl estradiol-cyproterone acetate treatment on metabolic syndrome, fat distribution and carotid intima media thickness in polycystic ovary syndrome
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Effects of ethinyl estradiol-cyproterone acetate treatment on metabolic syndrome, fat distribution and carotid intima media thickness in polycystic ovary syndrome

机译：乙炔雌二醇-醋酸环丙孕酮治疗对多囊卵巢综合征代谢综合征，脂肪分布和颈动脉内膜中层厚度的影响

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摘要

Objective: To evaluate the effects of ethinyl estradiol-cyproterone acetate (EE-CA) treatment on metabolic and cardiovascular risk factors, and body fat distribution in polycystic ovary syndrome (PCOS) after 6-month treatment. Subjects and methods: Thirty women with PCOS were evaluated before and after 6 months of EE-CA treatment. Anthropometrical measurements, hormonal levels, lipid and glucose profile were evaluated. Body fat thickness in four regions and carotid intima media thickness (IMT) were measured. Interval change in antropometric measurements, glucose and lipid profile, carotid IMT and body fat distribution was evaluated before and after 6-month EE-CA treatment. Results: FerrimanGallwey score and serum testosterone levels were significantly decreased after EE-CA treatment (p<0.01). No significant effect was detected on insulin resistance, lipid profile and carotid artery IMT. The visceral, subcutaneous and preperitoneal fat thicknesses decreased, and mid-thigh fat thickness increased after treatment period. However, only the alteration in subcutaneous fat thickness achieved a statistical significance (p<0.01). Conclusion: The EE-CA is an effective regimen in treatment of hirsutism and menstrual regulation. Although it provides significant decrease in subcutaneous fat thickness after 6-month treatment, it has no beneficial effect with respect to visceral fat thickness, metabolic and cardiovascular risk factors.
机译：目的：评价乙炔雌二醇环丙孕酮（EE-CA）治疗对六个月治疗后多囊卵巢综合征（PCOS）代谢和心血管危险因素以及体脂分布的影响。受试者和方法：在EE-CA治疗6个月之前和之后对30名患有PCOS的妇女进行了评估。人体测量，荷尔蒙水平，脂质和葡萄糖概况进行了评估。测量四个区域的体脂厚度和颈动脉内膜中层厚度（IMT）。在6个月的EE-CA治疗前后，评估了风速测定法，葡萄糖和脂质谱，颈动脉IMT和体内脂肪分布的间隔变化。结果：EE-CA治疗后FerrimanGallwey评分和血清睾丸激素水平显着降低（p <0.01）。没有发现对胰岛素抵抗，血脂和颈动脉IMT有明显影响。治疗后，内脏，皮下和腹膜前脂肪厚度减少，大腿中部脂肪厚度增加。但是，只有皮下脂肪厚度的变化才具有统计学意义（p <0.01）。结论：EE-CA是治疗多毛症和月经调节的有效方案。尽管经过6个月的治疗后皮下脂肪厚度显着降低，但对内脏脂肪厚度，代谢和心血管危险因素没有有益的作用。

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