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首页> 外文期刊>Expert review of anti-infective therapy >Immunopathogenesis of falciparum malaria: implications for adjunctive therapy in the management of severe and cerebral malaria.
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Immunopathogenesis of falciparum malaria: implications for adjunctive therapy in the management of severe and cerebral malaria.

机译：恶性疟疾的免疫发病机制：在严重和脑部疟疾管理中辅助治疗的意义。

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摘要

Despite optimal antimalarial treatment and advances in malaria eradication, the mortality rate associated with severe malaria due to Plasmodium falciparum infection, including cerebral malaria (CM), remains unacceptably high. This suggests that strategies directed solely at parasite eradication may be insufficient to prevent neurological complications and death in all cases of CM. Therefore, there is an urgent need to develop innovative adjunctive therapeutic strategies to effectively reduce CM-associated mortality. CM pathogenesis is believed to be due, in part, to an aberrant host immune response to P. falciparum, resulting in deleterious consequences, including vascular activation and dysfunction. Development of effective and affordable therapeutic strategies that act to modulate the underlying host-mediated immunopathology should be explored to improve outcome. In this article, we summarize immunomodulatory therapies that have been assessed in clinical trials to date, and highlight novel and promising treatment strategies currently being investigated to address this major global health challenge.
机译：尽管进行了最佳的抗疟疾治疗并在消除疟疾方面取得了进展，但由于恶性疟原虫感染，包括脑部疟疾（CM）而导致的严重疟疾相关的死亡率仍然很高。这表明仅针对寄生虫根除的策略可能不足以预防所有CM病例的神经系统并发症和死亡。因此，迫切需要开发创新的辅助治疗策略以有效降低CM相关死亡率。据信CM发病机理部分是由于宿主对恶性疟原虫的免疫反应异常，导致有害后果，包括血管活化和功能障碍。应该探索开发有效且负担得起的治疗策略，以调节潜在的宿主介导的免疫病理学，以改善疗效。在本文中，我们总结了迄今为止在临床试验中评估过的免疫调节疗法，并重点介绍了目前正在研究以应对这一重大全球健康挑战的新颖而有希望的治疗策略。

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