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首页> 外文期刊>Foot and ankle international >Healing of Achilles tendon, an experimental study: part 2--Histological, immunohistological and ultrasonographic analysis.
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Healing of Achilles tendon, an experimental study: part 2--Histological, immunohistological and ultrasonographic analysis.

机译：阿基里斯腱的愈合，一项实验研究：第2部分-组织学，免疫组织学和超声检查分析。

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In 105 rabbits the course of healing was examined at one, two, four, eight and 12 weeks (21 rabbits per group) after an experimental Achilles tendon rupture. The following treatment modalities were compared: A) primary functional treatment; B) operative functional treatment (resorbable suture); and C) operative functional treatment with fibrin glue. For the functional (after)-treatment a special orthosis was applied. A 7.5 MHz Ultrasound probe was used for ultrasonographic evaluation. The histological specimens were stained in Masson-Goldner and Azan technique. Collagen Type III was depicted immunhistologically. A semiquantitative fibrocyte count was performed. The histological results showed a smooth healing in the primary functional treatment group (A), reaching parallel orientation of collagen fibers at 12 weeks. In the suture group (B), a secondary gapping of the tendon stumps was detectable after one week as in all other groups. In the fibrin group (C), the fibrin was resorbed after four weeks without essential influence to the course of healing. At 12 weeks the histological evaluation in all groups showed approximately normal tendon pattern. Immunohistochemically, all groups showed cell-associated positive reactions for type-III collagen after one week with a maximum after two weeks. The semiquantitative fibrocyte count in the primary functional group showed a maximal number after one week. In the fibrin glue and suture groups the maximal number could be found after two weeks. Sonographically an increase in tendon thickness was detectable up to the fourth week in all groups. The secondary gapping of the tendon stumps in the suture group could also be detected sonographically. The echogenicity of the tendon during the course of healing showed increasing homogeneity and parallelism in all groups. At 12 weeks the echogenicity was comparable in all groups. The experiment suggests the equivalence of primary functional treatment to a combination of operative and functional therapy in Achilles tendon rupture.
机译：在实验性跟腱断裂后的1、2、4、8、12周（每组21只兔子）中检查了105只兔子的愈合过程。比较了以下治疗方式：A）主要功能治疗; B）手术功能性治疗（可吸收缝合线）; C）用纤维蛋白胶进行功能性治疗。对于功能性（后）治疗，应用了特殊的矫形器。 7.5 MHz超声探头用于超声检查评估。组织学标本用Masson-Goldner和Azan技术染色。免疫组织学描述了III型胶原。进行半定量纤维细胞计数。组织学结果显示主要功能治疗组（A）的愈合良好，在12周时达到胶原纤维的平行方向。在缝合线组（B）中，与所有其他组一样，在一周后可检测到肌腱残端的继发性间隙。在纤维蛋白组（C）中，纤维蛋白在四周后被吸收，而对愈合过程没有实质性影响。在第12周，所有组的组织学评估显示出大致正常的肌腱模式。免疫组织化学分析，所有组在1周后均显示出与细胞相关的III型胶原阳性反应，在2周后达到最大。初级功能组的半定量纤维细胞计数在一周后显示最大值。在纤维蛋白胶和缝合线组中，两周后可以找到最大数量。在超声检查中，在所有组中直到第四周都可以检测到肌腱厚度的增加。缝线组中肌腱残端的继发性间隙也可通过超声检查发现。在愈合过程中，腱的回声显示出所有组的同质性和平行性均在增加。在第12周，所有组的回声性均相当。实验表明，跟腱断裂中，主要功能治疗等同于手术和功能治疗相结合。

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