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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Tissue elastance influences airway smooth muscle shortening: comparison of mechanical properties among different species.
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Tissue elastance influences airway smooth muscle shortening: comparison of mechanical properties among different species.

机译：组织弹性影响气道平滑肌的缩短：不同物种之间机械性能的比较。

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摘要

We have observed striking differences in the mechanical properties of airway smooth muscle preparations among different species. In this study, we provide a novel analysis on the influence of tissue elastance on smooth muscle shortening using previously published data from our laboratory. We have found that isolated human airways exhibit substantial passive tension in contrast to airways from the dog and pig, which exhibit little passive tension (<5% of maximal active force versus approximately 60% for human bronchi). In the dog and pig, airway preparations shorten up to 70% from Lmax (the length at which maximal active force occurs), whereas human airways shorten by only approximately 12% from Lmax. Isolated airways from the rabbit exhibit relatively low passive tension (approximately 22% Fmax) and shorten by 60% from Lmax. Morphologic evaluation of airway cross sections revealed that 25-35% of the airway wall is muscle in canine, porcine, and rabbit airways in contrast to approximately 9% in human airway preparations. We postulate that the large passive tension needed to stretch the muscle to Lmax reflects the high connective tissue content surrounding the smooth muscle, which limits shortening during smooth muscle contraction by imposing an elastic load, as well as by causing radial constraint.
机译：我们已经观察到不同物种之间的气道平滑肌制剂的机械性能的显着差异。在这项研究中，我们使用我们实验室以前发布的数据，对组织弹性对平滑肌缩短的影响提供了新颖的分析。我们已经发现，与来自狗和猪的气道相比，孤立的人的气道表现出相当大的被动张力，而狗和猪的气道几乎没有被动张力（<最大主动力的5％，而对于人支气管则为大约60％）。在狗和猪中，气道准备比Lmax缩短最多70％（出现最大作用力的长度），而人的气道仅比Lmax缩短大约12％。与兔子隔离的呼吸道表现出相对较低的被动张力（大约为Fmax的22％），与Lmax相比缩短了60％。气道横截面的形态学评估显示，犬，猪和兔气道中25％至35％的气道壁是肌肉，而人类气道制剂中的气道壁约为9％。我们假定将肌肉拉伸至Lmax所需的较大被动张力反映了平滑肌周围的高结缔组织含量，这通过施加弹性载荷以及引起径向约束来限制平滑肌收缩过程中的缩短。

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