• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Marked depression of radiation-induced emesis in frogs following prior exposure to a brief dose of X-rays.
【24h】

Marked depression of radiation-induced emesis in frogs following prior exposure to a brief dose of X-rays.

机译：预先暴露于短剂量的X射线后，青蛙引起的呕吐呕吐明显降低。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Acute emesis response to harmful doses of X-rays on frogs (Rana porosa porosa) was examined. Results showed that the number of radioemesis events following exposure to 0.85 Gy was slightly higher than in the sham control animals. The increase in emesis action became more pronounced when the total dose of radiation was raised to 2.5 Gy. Only 1 frog out of a total of 12 did not show vomiting following radiation, while no response was observed in sham control animals. Note that animals in which the low dose rate of radiation was applied to whole body did not display any changes in the emesis response relative to control animals. The present studies, and those by others, showed that a brief dose of X-rays prior to a second exposure to a sub-lethal dose might induce a tolerance to radiation. An additional experiment was conducted to examine whether a small conditioning dose could induce a depression of radioemesis (tolerance) following an exposure to high dose X-ray. With prior exposure to 0.3 Gy, only 1 frog out of a total of 5 frogs vomited as a result of radiation exposure. Suppression of the emetic response became significant when the pre-radiation dose was decreased to 0.1 Gy. On the contrary, increasing the small conditioning dose to 0.5 Gy resulted in a remarkable rise of radiation-induced emesis. This results indicate that exposure to the smaller dose of X-rays elicits a tolerance effect to toxic dose level of radiation.
机译：检查了对青蛙（Rana porosa porosa）的X射线有害剂量的急性呕吐反应。结果表明，暴露于0.85 Gy后的放射呕吐事件的数量略高于假对照组动物。当辐射的总剂量增加到2.5 Gy时，呕吐作用的增加变得更加明显。在总共12只青蛙中，只有1只青蛙在辐射后没有呕吐，而在假对照动物中没有观察到反应。注意，相对于对照动物，向全身施加低辐射剂量率的动物没有表现出呕吐反应的任何变化。本研究以及其他研究表明，在第二次暴露于亚致死剂量之前，短暂的X射线剂量可能会引起对辐射的耐受性。进行了另一项实验，以检查小剂量的调理剂量在暴露于高剂量的X射线后是否会引起放射呕吐的降低（耐受性）。在事先暴露于0.3 Gy的情况下，由于辐射暴露，总共5只青蛙中只有1只青蛙呕吐。当放疗前剂量降至0.1 Gy时，催吐反应的抑制作用变得明显。相反，将少量调理剂量增加至0.5 Gy会导致辐射引起的呕吐显着增加。该结果表明，暴露于较小剂量的X射线会引起对辐射的有毒剂量水平的耐受性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号