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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Actions of excitatory amino acids on mesencephalic trigeminal neurons.
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Actions of excitatory amino acids on mesencephalic trigeminal neurons.

机译：兴奋性氨基酸对中脑三叉神经元的作用。

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Mesencephalic trigeminal (MeV) neurons are primary sensory neurons of which the cell soma is located within the brainstem, and is associated with synaptic contacts. In previous studies it has been reported that these cells are resistant to kainic acid excitotoxicity, and have little or no responsiveness to exogenously applied glutamate or selective agonists. In an in vitro slice preparation with intracellular recording, we have found that these cells respond to pressure-applied glutamate, N-methyl-D-aspartic acid (NMDA), kainate (KA), and (R,S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA). The kainate and AMPA responses appear to be mediated by different receptors, at least in part, since they exhibit differing sensitivity to an AMPA receptor selective antagonist. The agonists generally evoke larger responses than glutamate and exhibit a long-duration desensitization requiring approximately 10 min for full recovery. Some cross-desensitization between the glutamate agonists is also observed. Mesencephalic trigeminal neurons exhibit high-frequency oscillatory activity during depolarizations that approach threshold potentials, and these could combine with transmitter-induced depolarizations to enhance the excitability of these cells. Previous reports of nonsensitivity to glutamate and to kainate excitotoxicity are attributable to relatively small responses, and to the desensitization expressed by these neurons.
机译：中脑三叉神经（MeV）神经元是主要的感觉神经元，其细胞体位于脑干内，并与突触接触相关。在先前的研究中，已经报道了这些细胞对海藻酸兴奋性毒性具有抗性，并且对外源施用的谷氨酸或选择性激动剂几乎没有或没有响应性。在具有细胞内记录的体外切片制备中，我们发现这些细胞对压力施加的谷氨酸，N-甲基-D-天冬氨酸（NMDA），海藻酸盐（KA）和（R，S）-α-氨基有反应-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）。海藻酸酯和AMPA应答似乎至少部分地由不同的受体介导，因为它们对AMPA受体选择性拮抗剂表现出不同的敏感性。激动剂通常比谷氨酸盐引起更大的反应，并且表现出长时间的脱敏，需要约10分钟才能完全恢复。还观察到谷氨酸激动剂之间的一些交叉脱敏。中脑三叉神经元在去极化过程中表现出高频振荡活动，接近阈值电位，这些可以与递质诱导的去极化结合以增强这些细胞的兴奋性。以前对谷氨酸和红藻氨酸酯兴奋性毒性不敏感的报道归因于相对较小的反应以及这些神经元表达的脱敏作用。

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