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首页> 外文期刊>Foodborne pathogens and disease >Increased recognition of Non-O157 shiga toxin-producing escherichia coli infections in the United States during 2000-2010: Epidemiologic features and comparison with E. coli O157 infections
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Increased recognition of Non-O157 shiga toxin-producing escherichia coli infections in the United States during 2000-2010: Epidemiologic features and comparison with E. coli O157 infections

机译：在2000-2010年期间，美国对非O157产志贺毒素的大肠杆菌感染的认识增加：流行病学特征及其与O157大肠杆菌感染的比较

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Background: Shiga toxin-producing Escherichia coli (STEC) are an important cause of diarrhea and the major cause of postdiarrheal hemolytic uremic syndrome. Non-O157 STEC infections are being recognized with greater frequency because of changing laboratory practices. Methods: Foodborne Diseases Active Surveillance Network (FoodNet) site staff conducted active, population-based surveillance for laboratory-confirmed STEC infections. We assessed frequency and incidence of STEC infections by serogroup and examined and compared demographic factors, clinical characteristics, and frequency of international travel among patients. Results: During 2000-2010, FoodNet sites reported 2006 cases of non-O157 STEC infection and 5688 cases of O157 STEC infections. The number of reported non-O157 STEC infections increased from an incidence of 0.12 per 100,000 population in 2000 to 0.95 per 100,000 in 2010; while the rate of O157 STEC infections decreased from 2.17 to 0.95 per 100,000. Among non-O157 STEC, six serogroups were most commonly reported: O26 (26%), O103 (22%), O111 (19%), O121 (6%), O45 (5%), and O145 (4%). Non-O157 STEC infections were more common among Hispanics, and infections were less severe than those caused by O157 STEC, but this varied by serogroup. Fewer non-O157 STEC infections were associated with outbreaks (7% versus 20% for O157), while more were associated with international travel (14% versus 3% for O157). Conclusions: Improved understanding of the epidemiologic features of non-O157 STEC infections can inform food safety and other prevention efforts. To detect both O157 and non-O157 STEC infections, clinical laboratories should routinely and simultaneously test all stool specimens submitted for diagnosis of acute community-acquired diarrhea for O157 STEC and for Shiga toxin and ensure that isolates are sent to a public health laboratory for serotyping and subtyping.
机译：背景：产生志贺毒素的大肠杆菌（STEC）是腹泻的重要原因，也是腹泻后溶血性尿毒症综合征的主要原因。由于实验室做法的变化，人们越来越多地认识到非O157 STEC感染。方法：食源性疾病主动监视网络（FoodNet）的现场工作人员对实验室确认的STEC感染进行了基于人群的主动监视。我们通过血清组评估了STEC感染的频率和发生率，并检查并比较了人口统计学因素，临床特征和患者之间的国际旅行频率。结果：在2000-2010年期间，FoodNet网站报告了2006年非O157 STEC感染病例和5688例O157 STEC感染病例。报告的非O157 STEC感染数量从2000年的每100,000人口0.12例增加到2010年的每100,000例0.95例;而O157 STEC感染率从每100,000例2.17降至0.95。在非O157 STEC中，最常见的六个血清群是：O26（26％），O103（22％），O111（19％），O121（6％），O45（5％）和O145（4％）。非O157 STEC感染在西班牙裔患者中更为常见，并且感染的严重程度不及O157 STEC所引起的感染，但这随血清群的不同而不同。非O157 STEC感染与疾病暴发相关的发生率较低（O157为7％，而O157为20％），而与国际旅行有关的疾病更多（O157为14％对3％）。结论：对非O157 STEC感染的流行病学特征的加深了解可以为食品安全和其他预防工作提供信息。为了同时检测O157和非O157 STEC感染，临床实验室应常规并同时测试所有提交的粪便标本，以诊断O157 STEC和志贺毒素的急性社区获得性腹泻，并确保将分离株送至公共卫生实验室进行血清分型和子类型化。

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