Enhanced strand break induction of DNA by resonant metal-innershell photoabsorption.

Le-Sech C; Takakura K; Saint-Marc C; Frohlich H; Charlier M; Usami N; Kobayashi K

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Enhanced strand break induction of DNA by resonant metal-innershell photoabsorption.

机译：通过共振金属内壳光吸收增强DNA的链断裂诱导。

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We determined the number of single and double strand breaks (ssb and dsb) in a DNA-chloroterpyridine platinum complex induced by resonant photoabsorption in the L(III) innershell of a platinum atom. The number of ssb and dsb were measured in supercoiled plasmids (AG30) versus the chloroterpyridine platinum concentration, i.e., the ratio of intercalated molecules to the number of phosphate sites in DNA. A significant increase in the number of ssb and dsb was observed when the DNA contained intercalated molecules. This technique is an efficient way to induce ssb and dsb triggered by the atomic Auger effect.

机译：我们确定了由铂原子的L（III）内壳中的共振光吸收引起的DNA-氯代吡啶吡啶铂络合物中单链和双链断裂（ssb和dsb）的数量。在超螺旋质粒（AG30）中测量ssb和dsb的数目相对于氯代吡啶吡啶的浓度，即插入分子与DNA中磷酸位点数目的比率。当DNA包含插入分子时，观察到ssb和dsb的数量显着增加。该技术是诱导由原子俄歇效应触发的ssb和dsb的有效方法。

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《Canadian Journal of Physiology and Pharmacology》 |2001年第2期|共5页
作者
Le-Sech C; Takakura K; Saint-Marc C; Frohlich H; Charlier M; Usami N; Kobayashi K;
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正文语种 eng
中图分类人体生理学;药理学;生理学;药学;
关键词
DNA Damage; DNA; Superhelical; Intercalating Agents; Metals; Organoplatinum Compounds; DNA损伤;

机译：DNA损伤;DNA;超螺旋;嵌入剂;金属;有机铂化合物;DNA损伤;

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1. Enhanced strand break induction of DNA by resonant metal-innershell photoabsorption. [J] . Le-Sech C, Takakura K, Saint-Marc C, Canadian Journal of Physiology and Pharmacology . 2001,第2期

机译：通过共振金属内壳光吸收增强DNA的链断裂诱导。
2. Induction of DNA double-strand breaks by zeocin in Chlamydomonas reinhardtii and the role of increased DNA double-strand breaks rejoining in the formation of an adaptive response [J] . S. G. Chankova, E. Dimova, M. Dimitrova, Radiation and Environmental Biophysics . 2007,第4期

机译：zeocin在莱茵衣藻中诱导DNA双链断裂，而增加的DNA双链断裂在重新形成适应性反应中的作用
3. Induction of DNA double-strand breaks by zeocin in Chlamydomonas reinhardtii and the role of increased DNA double-strand breaks rejoining in the formation of an adaptive response [J] . S.G.Chankova, E.Dimova, M.Dimitrova Radiation and Environmental Biophysics . 2007,第4期

机译：zeocin在莱茵衣藻中诱导DNA双链断裂，而增加的DNA双链断裂在重新形成适应性反应中的作用
4. Modifying Effect of Different Forms of Lipid A on the Induction of DNA Double-Strand Breaks in Mice Hippocampal Cells After Exposure to Ionizing Radiation of Different Quality in Vitro [C] . Eugenia A. Kuzmina, Vladimir N. Chausov, Martina Dubnickova, International Scientific Conference of Young Scientists and Specialists . 2019

机译：不同形式的脂质A对小鼠海马细胞诱导在暴露于不同品质的电离辐射后DNA双链诱导的影响
5. The induction of apoptosis by the E2F1 transcription factor and the emergence of a role for E2F1 in the DNA double strand break response . [D] . Powers, John Thomas, Jr. 2006

机译：诱导细胞凋亡的E2F1转录因子和出现的作用E2F1在DNA双链断裂反应。
6. Homologous recombination in plant cells is enhanced by in vivo induction of double strand breaks into DNA by a site-specific endonuclease. [O] . H Puchta, B Dujon, B Hohn 1993

机译：植物细胞中的同源重组通过位点特异性核酸内切酶在体内诱导双链断裂进入DNA而得以增强。
7. Homologous recombination in plant cells is enhanced by in vivo induction of double strand breaks into DNA by a site-specific endonuclease. [O] . Puchta, H, Dujon, B, Hohn, B 1993

机译：植物细胞中的同源重组通过位点特异性核酸内切酶在体内诱导双链断裂进入DNA而得以增强。

Enhanced strand break induction of DNA by resonant metal-innershell photoabsorption.

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