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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Reduced baroreceptor sensitivity during hypotension in ANP-knockout mice.
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Reduced baroreceptor sensitivity during hypotension in ANP-knockout mice.

机译：ANP基因敲除小鼠低血压期间压力感受器敏感性降低。

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摘要

We studied baroreflex gain in inactin-anesthetized mice that had been genetically modified to be depleted of atrial natriuretic peptide (ANP -/-). Wild-type mice (ANP +/+) served as controls. ANP -/- mice had a significantly higher basal arterial blood pressure (ABP) than ANP +/+ mice [112+/-7 vs. 80+/-5 mmHg (mean +/- SEM)]. Their basal heart rates were not different (491+/-13 vs. 446+/-19 bpm). A third group, composed of ANP +/+ mice only, was rendered acutely hypertensive by an intravenous infusion of arginine vasopressin acetate (0.3 pg bolus followed by 0.3 pg/h) so as to serve as a control for the elevated ABP in the ANP -/- mice. Transient changes in ABP were caused by bolus injections of oxymetazoline hydrochloride (1.5-3 ng) or sodium nitroprusside (20-100 ng). Baroreflex gain was calculated as the ratio of the peak heart rate change that followed the peak change in mean ABP resulting from injection of oxymetazoline or nitroprusside. There were no significant differences among the groups in their responses to transient hypertension. On the other hand, the ANP -/- mice showed a significantly depressed tachycardic response to transient hypotension when compared with the other two groups. We conclude that the ANP -/- mice are unable to increase efferent sympathetic nervous activity adequately above the high basal activity that is a feature of this animal model.
机译：我们研究了已被基因修饰以减少心房利钠肽（ANP-/-）的经肌动蛋白麻醉的小鼠的压力反射增益。野生型小鼠（ANP + / +）用作对照。 ANP-/-小鼠的基础动脉血压（ABP）明显高于ANP + / +小鼠[112 +/- 7对80 +/- 5 mmHg（平均+/- SEM）]。他们的基础心率没有差异（491 +/- 13与446 +/- 19 bpm）。第三组仅由ANP + / +小鼠组成，通过静脉输注精氨酸加压素醋酸盐（0.3 pg推注，然后0.3 pg / h）使其急性高血压，以作为ANP中ABP升高的对照-/- 老鼠。 ABP的瞬时变化是由大剂量注射盐酸羟甲唑啉（1.5-3 ng）或硝普钠（20-100 ng）引起的。压力反射增益的计算是峰值心率变化与继注射羟甲唑啉或硝普钠导致的平均ABP峰值变化之比。各组对短暂性高血压的反应无显着差异。另一方面，与其他两组相比，ANP-/-小鼠对短暂性低血压的心动过速反应显着降低。我们得出结论，ANP-/-小鼠不能充分增加传出的交感神经活动，超过该动物模型的特征之一就是高基础活动。

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