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Hypothalamic-Brainstem Circuits Controlling Eating

机译：下丘脑-脑干电路控制饮食

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It is now axiomatic that neurons in the hypothalamic arcuate nucleus have a primary role in responding to changes in circulating levels of leptin and transmitting signals to downstream circuits that influence eating and energy expenditure. Signals generated from the gastrointestinal tract during meals reach the brainstem, via the vagus nerve and other routes, and impinge on neural circuits that influence the timing and size of meals and amount of food consumed. One of the mechanisms by which leptin exerts its anorexic effects is by increasing the effectiveness of intestinal signals that cause satiation during a meal. It is clear that the effects of gut satiation signals such as CCK can be amplified by leptin acting in the CNS, and in the arcuate nucleus in particular. The present article describes the state of our knowledge about specific neural circuits between the hypothalamus and brainstem that play a role in the interaction of leptin and meal-control signals to control food intake.
机译：显然，下丘脑弓状核中的神经元在响应瘦素循环水平的变化并将信号传输到影响进食和能量消耗的下游回路中起主要作用。进餐时胃肠道产生的信号通过迷走神经和其他途径到达脑干，并撞击到影响进餐时间和量以及进食量的神经回路。瘦素发挥其厌食作用的机制之一是通过增加进餐时引起饱腹感的肠信号的有效性。显然，肠瘦饱信号如CCK的作用可以通过瘦素在CNS中，特别是在弓形核中的作用而放大。本文介绍了我们关于下丘脑和脑干之间特定神经回路的知识状态，这些神经回路在瘦素和膳食控制信号相互作用以控制食物摄入中发挥作用。

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