...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Thyroid hormone and cardiac repair/regeneration: From prometheus myth to reality?
【24h】

Thyroid hormone and cardiac repair/regeneration: From prometheus myth to reality?

机译：甲状腺激素与心脏修复/再生：从普罗米修斯神话到现实？

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Nature's models of repair and (or) regeneration provide substantial evidence that a natural healing process may exist in the heart. The potential for repair and (or) regeneration has been evolutionarily conserved in mammals, and seems to be restricted to the early developmental stages. This window of regeneration is reactivated during the disease state in which fetal gene reprogramming occurs in response to stress. Analogies exist between the damaged and developing heart, indicating that a regulatory network that drives embryonic heart development may control aspects of heart repair and (or) regeneration. In this context, thyroid hormone (TH), which is a critical regulator of the maturation of the myocardium, appears to have a reparative role later in adult life. Changes in TH - thyroid hormone receptor (TR) homeostasis govern the return of the injured myocardium to the fetal phenotype. Accordingly, TH can induce cardiac repair and (or) regeneration by reactivating developmental gene programming. As a proof of concept in humans, TH is found to be an independent determinant of functional recovery and mortality after myocardial infarction. The potential of TH to regenerate and (or) repair the ischemic myocardium is now awaited to be tested in clinical trials.
机译：大自然的修复和（或）再生模型为心脏可能存在自然愈合过程提供了充分的证据。修复和（或）再生的潜力已在哺乳动物中得到了进化保留，并且似乎仅限于早期发育阶段。在疾病状态下该再生窗口被重新激活，在该疾病状态下，胎儿基因响应于压力而重新编程。在受损心脏和发育中的心脏之间存在类比，表明驱动胚胎心脏发育的调控网络可能控制心脏修复和（或）再生的各个方面。在这种情况下，甲状腺激素（TH）是心肌成熟的重要调节剂，在成年后期似乎具有修复作用。 TH-甲状腺激素受体（TR）稳态的变化决定着受伤的心肌向胎儿表型的恢复。因此，TH可以通过重新激活发育基因程序来诱导心脏修复和/或再生。作为人类概念的证明，TH是心肌梗死后功能恢复和死亡率的独立决定因素。现在正在临床上测试TH再生和（或）修复缺血性心肌的潜力。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号