Are immunoglobulin G4-positive multiorgan lymphoproliferative syndrome and autoimmune pancreatitis different manifestations of a common clinicopathologic entity?

Chiba T

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Are immunoglobulin G4-positive multiorgan lymphoproliferative syndrome and autoimmune pancreatitis different manifestations of a common clinicopathologic entity?

机译：免疫球蛋白G4阳性的多器官淋巴组织增生综合征和自身免疫性胰腺炎是否是常见临床病理实体的不同表现？

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Autoimmune pancreatitis (AIP), also known as lym-phoplasmacytic sclerosing pancreatitis, was first described by Sarles et al in 1961 (Am J Dig Dis 1961;6:688-698), and its recognition as a distinctive type of pancreatitis has been mainly developed in Japan between the mid 1980s and the early 1990s (Dig Dis Sci 1995;40:1561-1568). AIP is now generally accepted as a special type of pancreatitis that involves autoimmune mechanisms. An association between AIP and increased serum immunoglobulin (Ig) G4 levels was first reported by Hamano et al in 2001(N Engl J Med 2001;344:732-738), and an increased serum IgG4 level is now considered the best serum marker for diagnosing AIP. AIP is associated frequently with extrapancreatic diseases including sclerosing sia-loadenitis and lacrimal gland inflammation, sclerosing cholangitis, retroperitoneal fibrosis, and enlarged celiac and hilar lymph nodes, suggesting that AIP is a systemic autoimmune disorder characterized by high serum IgG4 levels (J Gastroenterol 2003;38:982-984).

机译：自身免疫性胰腺炎（AIP），也称为淋巴-胞浆性硬化性胰腺炎，最早由Sarles等人于1961年描述（Am J Dig Dis 1961; 6：688-698），其主要特征是公认的一种独特的胰腺炎在1980年代中期至1990年代初在日本开发（Dig Dis Sci 1995; 40：1561-1568）。现在，AIP被普遍认为是一种涉及自身免疫机制的特殊类型的胰腺炎。 Hamano等人于2001年首次报道了AIP与血清免疫球蛋白（Ig）G4水平升高之间的关联（N Engl J Med 2001; 344：732-738），而现在血清IgG4水平升高被认为是AIP的最佳血清标记诊断AIP。 AIP常与胰腺外疾病有关，包括硬化性唾液腺炎和泪腺炎，硬化性胆管炎，腹膜后纤维化以及腹腔和肺门淋巴结肿大，这表明AIP是一种以血清IgG4高水平为特征的全身性自身免疫疾病（J Gastroenterol 2003; 38：982-984）。

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《Gastroenterology》 |2010年第2期|共4页
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Chiba T;
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中图分类消化系及腹部疾病;
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1. Are immunoglobulin G4-positive multiorgan lymphoproliferative syndrome and autoimmune pancreatitis different manifestations of a common clinicopathologic entity? [J] . Chiba T Gastroenterology . 2010,第2期

机译：免疫球蛋白G4阳性的多器官淋巴组织增生综合征和自身免疫性胰腺炎是否是常见临床病理实体的不同表现？
2. Immunoglobulin G4-positive multi-organ lymphoproliferative syndrome with antiphospholipid antibody syndrome [J] . KawakamiN., KawaiK., BabaN., The Journal of dermatology . 2012,第7期

机译：免疫球蛋白G4阳性的多器官淋巴组织增生综合征与抗磷脂抗体综合征
3. Clinical and pathological differences between serum immunoglobulin G4-positive and-negative type 1 autoimmune pancreatitis [Lakrimal kese dakriolitleri-patogenez ve bile?im] [J] . PaikW.H., RyuJ.K., ParkJ.M., World journal of gastroenterology : . 2013,第25期

机译：血清免疫球蛋白G4阳性和阴性1型自身免疫性胰腺炎的临床和病理学差异[Lakrimal kese dakriolitleri-patogenez ve bile？im]
4. The Role of Acinar Cells Function in Oral and Gut Microbiota in Autoimmune Pancreatitis and Sj?gren's Syndrome [D] . Kabrah, Ahmed. 2020

机译：丙氨酸细胞功能在口腔和肠道微生物中的作用在自身免疫性胰腺炎中和SJ？GREN的综合征
5. Unusual Multiorgan Immunoglobulin G4 (IgG4) Inflammation: Autoimmune Pancreatitis Mikulicz Syndrome and IgG4 Mastitis [O] . Petr Dítě, Jan Trna, Zdeněk Kinkor, 2013

机译：异常的多器官免疫球蛋白G4（IgG4）炎症：自身免疫性胰腺炎米库利兹综合征和IgG4乳腺炎
6. Unusual Multiorgan Immunoglobulin G4 (IgG4) Inflammation: Autoimmune Pancreatitis, Mikulicz Syndrome, and IgG4 Mastitis [O] . Petr Dítě, Jan Trna, Zdeněk Kinkor, 2013

机译：不寻常的多性免疫球蛋白G4（IgG4）炎症：自身免疫胰腺炎，Mikulicz综合征和IgG4乳腺炎

Are immunoglobulin G4-positive multiorgan lymphoproliferative syndrome and autoimmune pancreatitis different manifestations of a common clinicopathologic entity?

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