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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Inhibitory effect of gymnemic acid on intestinal absorption of oleic acid in rats.
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Inhibitory effect of gymnemic acid on intestinal absorption of oleic acid in rats.

机译：匙gym藤酸对大鼠肠内油酸吸收的抑制作用。

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摘要

Gymnemic acid, a mixture of triterpene glycosides extracted from the leaves of Gymnema sylvestre, is known to inhibit the intestinal absorption of glucose in human and rats. This work examined the effect of gymnemic acid on oleic acid absorption by the method of intestinal perfusion in rats. The results showed the following. (i) Gymnemic acid potently inhibited the absorption of oleic acid in intestine. (ii) This inhibition was dose dependent and reversible. (iii) The extent of inhibition and the recovery progress were extremely similar to that of glucose absorption. (iv) Taurocholate did not affect the inhibitory effect of gymnemic acid on oleic acid absorption, but lowering its concentration facilitated the recovery from the inhibition. (v) The absorption of oleic acid was not affected by other glycosides such as phloridzin, stevioside, and glycyrrhizin. These new findings are important for understanding the roles of gymnemic acid in therapy of diabetes mellitus and obesity.
机译：匙藤酸是从匙Gym藤叶中提取的三萜糖苷的混合物，已知能抑制人和大鼠肠道中葡萄糖的吸收。这项工作通过大鼠肠内灌流的方法检查了体操油对油酸吸收的影响。结果显示如下。 （i）匙Gym藤酸有力地抑制了肠道中油酸的吸收。 （ii）这种抑制是剂量依赖性的和可逆的。 （iii）抑制程度和恢复进展与葡萄糖吸收极其相似。 （iv）牛磺胆酸盐不影响匙gym藤酸对油酸吸收的抑制作用，但是降低其浓度有助于从抑制作用中恢复。 （v）油酸的吸收不受其他糖苷的影响，例如phloridzin，甜菊糖苷和甘草甜素。这些新发现对于理解体操油在糖尿病和肥胖症治疗中的作用非常重要。

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