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首页> 外文期刊>Future medicinal chemistry >N-heterocyclic carbene complexes of silver and gold as novel tools against breast cancer progression
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N-heterocyclic carbene complexes of silver and gold as novel tools against breast cancer progression

机译：银和金的N-杂环卡宾配合物是对抗乳腺癌进展的新工具

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Aim: Metal carbenic complexes have received considerable attention in both the catalysis and biological fields for their potential applications in cancer and antimicrobial therapies. Results: A small series of new silver and gold N-heterocyclic carbene complexes has been designed and synthesized. Among the tested complexes, one compound was particularly active in inhibiting anchorage-dependent and -independent breast cancer proliferation, and inducing cell apoptosis via a mitochondria-related process. The antitumor activity was associated to the transcriptional activation of the tumor suppressor gene p53 in an Sp1-dependent manner, as evidenced by biological and docking studies. Conclusion: Our results highlight the importance and the versatility of N-heterocyclic carbene complexes of gold and silver as useful tools against breast cancer progression.
机译：目的：金属羧酸配合物在癌症和抗菌疗法中的潜在应用已在催化和生物学领域引起了广泛关注。结果：设计并合成了一系列新的银和金N-杂环卡宾络合物。在测试的复合物中，一种化合物在抑制锚定依赖性和非依赖性乳腺癌的增殖以及通过线粒体相关过程诱导细胞凋亡方面特别有效。生物学和对接研究证明，抗肿瘤活性以Sp1依赖的方式与抑癌基因p53的转录激活有关。结论：我们的结果突出了金和银的N-杂环卡宾配合物作为对抗乳腺癌进展的有用工具的重要性和多功能性。

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