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首页> 外文期刊>Macromolecular chemistry and physics >Star-shaped block copolymers by copper-catalyzed azide-alkyne cycloaddition for potential drug delivery applications
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Star-shaped block copolymers by copper-catalyzed azide-alkyne cycloaddition for potential drug delivery applications

机译：铜催化的叠氮化物-炔烃环加成的星形嵌段共聚物在潜在的药物输送中的应用

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摘要

Star-shaped poly(μ-caprolactone) is synthesized by ring-opening polymerization and subsequently functionalized with alkyne groups. These are utilized for the attachment of linear poly(ethylene glycol) monomethyl ether azide (mPEG-N_3) and poly(2-ethyl-2-oxazoline) azide (PEtOx-N_3) by copper-catalyzed azide-alkyne cycloaddition (CuAAC). The resulting amphiphilic star-shaped block copolymers are characterized by SEC, MALDI-TOF mass spectrometry, NMR spectroscopy, and DLS. In order to elucidate the potential of both systems as drug carriers their loading capacity is studied with a model system, the hydrophobic dye fat brown RR. Furthermore, erythrocyte aggregation tests provide first indications that the two different star-shaped block copolymers are compatible for potential applications in a biological context.
机译：通过开环聚合合成星形聚（μ-己内酯），然后用炔基官能化。这些通过铜催化的叠氮化物-炔烃环加成反应（CuAAC）用于连接线性聚乙二醇单甲醚叠氮化物（mPEG-N_3）和聚2-乙基-2-恶唑啉叠氮化物（PEtOx-N_3）。所得的两亲星形嵌段共聚物通过SEC，MALDI-TOF质谱，NMR谱和DLS表征。为了阐明这两种系统作为药物载体的潜力，使用模型系统疏水染料发棕RR研究了它们的负载能力。此外，红细胞聚集测试提供了两种不同的星形嵌段共聚物在生物学环境中潜在应用相容的初步指示。

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