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首页> 外文期刊>Marine genomics >Transcriptomic analysis of Nodal- and BMP-associated genes during juvenile development of the sea urchin Heliocidaris erythrogramma
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Transcriptomic analysis of Nodal- and BMP-associated genes during juvenile development of the sea urchin Heliocidaris erythrogramma

机译：海胆小红斑鱼幼体发育过程中与节点和BMP相关基因的转录组学分析

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Understanding the unusual radial body plan of echinoderms and its relationship to the bilateral plan of other deuterostomes remains a challenge. The molecular processes of embryonic and early larval development in sea urchins are well characterised, but those giving rise to the adult and its radial body remain poorly studied. We used the developmental transcriptome generated for Heliocidaris etythrogramma, a species that forms the juvenile soon after gastrulation, to investigate changes in gene expression underlying radial body development. As coelomogenesis is key to the development of pentamery and juvenile formation on the left side of the larva, we focussed on genes associated with the nodal and BMP2/4 network that pattern this asymmetry. We identified 46 genes associated with this Nodal and BMP2/4 signalling network, and determined their expression profiles from the gastrula, through to rudiment development, metamorphosis and the fully formed juvenile. Genes associated with Nodal signalling shared similar expression profiles, indicating that they may have a regulatory relationship in patterning morphogenesis of the juvenile sea urchin. Similarly, many genes associated with BMP2/4 signalling had similar expression profiles through juvenile development. Further examination of the roles of Nodal- and BMP2/4-associated genes is required to determine function and whether the gene expression profiles seen in H. eiythrogramma are due to ongoing activity of gene networks established during early development, or to redeployment of regulatory cassettes to pattern the adult radial body plan. (C) 2015 Elsevier B.V. All rights reserved.
机译：了解棘皮动物的异常radial骨计划及其与其他氘核吻合口双侧计划的关系仍然是一个挑战。海胆的胚胎发育和幼虫早期发育的分子过程已被很好地表征，但是那些引起成年及其radial体的过程仍未得到很好的研究。我们使用为Heliocidaris etythrogramma（一种在消化后不久就形成少年的物种）产生的发育转录组来研究radial体发育背后的基因表达变化。由于成瘤作用是幼虫左侧五角体和幼体形成的关键，因此我们集中于与节点和BMP2 / 4网络相关的基因，该基因可形成这种不对称性。我们鉴定了与此Nodal和BMP2 / 4信号网络相关的46个基因，并确定了它们从下腹到胚发育，变态和完全成熟的幼虫的表达谱。与Nodal信号转导相关的基因具有相似的表达谱，表明它们在少年海胆的形态发生中可能具有调控关系。同样，与BMP2 / 4信号转导相关的许多基因在青少年发育过程中具有相似的表达谱。需要进一步检查与Nodal和BMP2 / 4相关的基因的作用，以确定功能以及在红细胞史中见到的基因表达谱是由于早期发育过程中建立的基因网络的持续活动，还是归因于调控盒的重新部署制定成人的body体计划。 （C）2015 Elsevier B.V.保留所有权利。

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