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Statistical coronary motion models for 2D+t/3D registration of X-ray coronary angiography and CTA

机译：X射线冠状动脉造影和CTA的2D + t / 3D配准的统计冠状动脉运动模型

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摘要

Accurate alignment of intra-operative X-ray coronary angiography (XA) and pre-operative cardiac CT angiography (CTA) may improve procedural success rates of minimally invasive coronary interventions for patients with chronic total occlusions. It was previously shown that incorporating patient specific coronary motion extracted from 4D CTA increases the robustness of the alignment. However, pre-operative CTA is often acquired with gating at end-diastole, in which case patient specific motion is not available. For such cases, we investigate the possibility of using population based coronary motion models to provide constraints for the 2D + t/3D registration. We propose a methodology for building statistical motion models of the coronary arteries from a training population of 4D CTA datasets. We compare the 2D + t/3D registration performance of the proposed statistical models with other motion estimates, including the patient specific motion extracted from 4D CTA, the mean motion of a population, the predicted motion based on the cardiac shape. The coronary motion models, constructed on a training set of 150 patients, had a generalization accuracy of 1. mm root mean square point-to-point distance. Their 2D + t/3D registration accuracy on one cardiac cycle of 12 monoplane XA sequences was similar to, if not better than, the 4D CTA based motion, irrespective of which respiratory model and which feature based 2D/3D distance metric was used. The resulting model based coronary motion estimate showed good applicability for registration of a subsequent cardiac cycle.
机译：术中X射线冠状动脉造影（XA）和术前心脏CT血管造影（CTA）的准确对准可提高慢性完全阻塞患者微创冠状动脉介入治疗的手术成功率。先前显示，合并从4D CTA提取的患者特定冠状动脉运动可提高对齐的鲁棒性。但是，术前CTA通常是在舒张末期通过门控获得的，在这种情况下，无法进行患者特定的运动。对于此类情况，我们调查了使用基于人群的冠状动脉运动模型为2D + t / 3D注册提供约束的可能性。我们提出了一种方法，可从4D CTA数据集的训练人群中构建冠状动脉的统计运动模型。我们将提议的统计模型的2D + t / 3D注册性能与其他运动估计值进行比较，包括从4D CTA中提取的患者特定运动，人群的平均运动，基于心脏形状的预测运动。在150名患者的训练集上构建的冠状动脉运动模型的泛化精度为1. mm均方根点对点距离。无论使用哪种呼吸模型和哪种基于特征的2D / 3D距离度量标准，它们在12个单平面XA序列的一个心动周期上的2D + t / 3D配准精度都与基于4D CTA的运动相似（如果不是更好）。所得基于模型的冠状动脉运动估计显示出良好的适用性，可用于后续心动周期的登记。

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