• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Medical and Pediatric Oncology: The Official Journal of the American Association for Cancer Education >Role of surgical biopsies in the management of bone marrow transplant patients.
【24h】

Role of surgical biopsies in the management of bone marrow transplant patients.

机译：手术活检在骨髓移植患者管理中的作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Bone marrow transplantation (BMT) patients frequently develop life-threatening problems that have similar clinical presentations but differing aetiologies. Despite intensive investigation by haematological, biochemical, and microbiological means, accurate diagnosis is not always possible. Histological and microbiological examination of biopsies from the affected organ may be indicated to enable an accurate diagnosis to be made in these patients. Here we assess the indications, findings, and outcomes in patients who have required surgical biopsy after BMT. PROCEDURE: We retrospectively reviewed all BMT patients who had surgical biopsies between February 1994 and January 1997. Twenty-six patients (1-46 years, median age 10 years) underwent 40 biopsies from the upper and lower GI tract, lung, or liver. Indications for BMT were: relapsed leukaemia = 18; other types of leukaemia = 3; aplastic anaemia=3; other diseases = 2. Type of BMT: matched related donor = 3, unrelated T-cell depleted donor = 23. RESULTS: Eleven (42%) cases had a change in management; 4 (16%) patients avoided further aggressive therapy because of poor prognosis. Unexpected diagnoses were found in 7 biopsies: 1 acute colitis, 1 duodenal ulcer, 1 liver aspergilloma, 2 transfusion siderosis, 1 radiation fibrosis of the lung, and 1 cytomegalovirus infection of the lung. Three patients were noted to have complications after their procedure. CONCLUSIONS: Surgical biopsies for undiagnosed problems can be of benefit in the management of very sick patients who have received bone marrow transplantations. Despite the fact that these patients are so unwell, there is a low rate of complications related to surgery and anaesthesia. Copyright 1999 Wiley-Liss, Inc.
机译：背景：骨髓移植（BMT）患者经常出现威胁生命的问题，具有相似的临床表现但病因不同。尽管通过血液，生物化学和微生物学方法进行了深入研究，但并非总是能够进行准确的诊断。可能需要对受累器官的活组织检查进行组织学和微生物学检查，以便能够对这些患者进行准确的诊断。在这里，我们评估了需要进行BMT手术活检的患者的适应症，发现和结果。程序：我们回顾性回顾了1994年2月至1997年1月之间所有接受手术活检的BMT患者。26例患者（1-46岁，中位年龄10岁）接受了40例上下胃肠道，肺或肝脏的活检。 BMT的适应症为：复发性白血病= 18;其他类型的白血病= 3;再生障碍性贫血= 3;其他疾病=2。BMT类型：相配的相关供体= 3，不相关的T细胞耗尽的供体=23。结果：11例（42％）病例的管理发生了改变; 4名（16％）患者由于预后不良而避免了进一步的积极治疗。在7例活检中发现了意外的诊断：1例急性结肠炎，1例十二指肠溃疡，1例肝曲霉菌，2例输血铁皮病，1例肺放射性纤维化和1例肺巨细胞病毒感染。注意到三名患者在手术后出现并发症。结论：对于未诊断出的问题进行手术活检可以在非常严重的接受骨髓移植的患者的治疗中受益。尽管这些患者身体不适，但与手术和麻醉有关的并发症发生率较低。版权所有1999 Wiley-Liss，Inc.

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号