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首页> 外文期刊>Medical and Pediatric Oncology: The Official Journal of the American Association for Cancer Education >Radiation-therapy effects on bone density.
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Radiation-therapy effects on bone density.

机译：放射治疗对骨密度的影响。

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摘要

Only limited data are available on the effects of radiation-therapy on the mineral content of the bone of children treated for malignancy. The incidence of osteopenia varies between 8 and 23%, but confounding factors were the use of chemotherapy and the effects of prophylactic cranial irradiation. The factors influencing bone atrophy are no more clearly defined in adults treated for cancer by high dose local radiation-therapy. Pathological observed in patient tissues, indicates a clear role for vascular changes in the development of osteopenia, although there remains some uncertainty as to the effects of osteoblast cell loss. Reduced blood flow in bone is clearly dose-related in experimental animal studies and after single doses of >20 Gy changes in bone mineral content have been found. However, this was only at late times (>/=30 weeks) after irradiation. The relationship between these changes and bone strength remains unproven because of the limited nature of many of the animal studies. Radiation dosefractionation data for rib-fracture in breast cancer patients suggests an alpha/beta ratio is in the range 1.8-2.8 Gy, comparable to values obtained for other late responding normal human tissues.
机译：关于放射疗法对接受恶性肿瘤治疗的儿童骨骼中矿物质含量的影响，只有有限的数据。骨质减少的发生率在8％到23％之间，但混杂因素是化学疗法的使用和预防性颅脑照射的影响。在通过高剂量局部放射疗法治疗癌症的成年人中，影响骨萎缩的因素尚未明确定义。在患者组织中观察到的病理学表明，在骨质减少的发展中，血管变化具有明显的作用，尽管对于成骨细胞损失的影响仍存在一些不确定性。在实验动物研究中，骨中血流量的减少显然与剂量有关，并且在单剂量> 20 Gy后发现骨矿物质含量发生了变化。但是，这仅在照射后的较晚时间（> / = 30周）。由于许多动物研究的有限性，这些变化与骨骼强度之间的关系尚未得到证实。乳腺癌患者肋骨骨折的放射剂量分馏数据表明，α/β比在1.8-2.8 Gy范围内，与其他晚期反应正常人体组织获得的值相当。

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