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首页> 外文期刊>Medicine and science in sports and exercise >Myosin heavy-chain mRNA expression after a single session of heavy-resistance exercise.
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Myosin heavy-chain mRNA expression after a single session of heavy-resistance exercise.

机译：单次高强度运动后，肌球蛋白重链mRNA的表达。

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PURPOSE: This study determined the effects of a single session of heavy-resistance exercise on myosin heavy-chain (MHC) mRNA expression, along with the expression of the transcription factors Myo-D, myogenin, and Id-1. METHODS: Four male subjects participated in a control group (CON) and seven in a resistance-exercise group (REX). REX performed one resistance-exercise session employing three sets of 8-10 repetitions at 75-80% one-repetition maximum on the squat, leg press, and leg extension. Vastus lateralis biopsies were obtained pre, post, and at 6 h postexercise. RESULTS: In regard to CON, no significant differences were located for any criterion variable (P > 0.05). For REX, elevations of 38.19%, 45.61%, and 74.24% (P < 0.05), respectively, occurred at 6 h-post for Type I, IIa, and IIx MHC mRNA. Myo-D and myogenin mRNA were elevated 27.28% and 23.58% postexercise (P < 0.05), respectively, but no change was observed in Id-1 mRNA. Elevations at 6 h-post of 46.85% and 46.41% (P < 0.05), respectively, occurred for Myo-D and myogenin mRNA with no change in Id-1. Myo-D and myogenin protein increased 57.91% and 52.30%, respectively, postexercise and 317.56% and 254.08 at 6 h-post (P < 0.05), whereas no change was noted for Id-1. Myofibrillar protein was elevated 84.52% at 6 h-post (P < 0.05). Type I and IIa MHC mRNA at 6 h-post were correlated with myogenin mRNA and protein postexercise and 6 h-post, whereas Type IIx at 6 h-post was correlated with Myo-D mRNA and protein postexercise and 6 h-post (P < 0.05). CONCLUSIONS: These results indicate that the mRNA expression of all three MHC isoforms is up-regulated after a single session of heavy-resistance exercise and that Myo-D and myogenin seem to play a role in MHC isoform gene expression.
机译：目的：本研究确定了单次重度抵抗运动对肌球蛋白重链（MHC）mRNA表达以及转录因子Myo-D，myogenin和Id-1表达的影响。方法：四名男性受试者参加了对照组（CON），而七名受试者参加了抵抗运动组（REX）。 REX进行了一次抵抗运动，进行三组8-10次重复练习，下蹲，压腿和下肢伸展的最大重复次数为75-80％。运动前，运动后和运动后6 h均取外侧股静脉活检。结果：关于CON，任何标准变量均无显着差异（P> 0.05）。对于REX，I型，IIa型和IIx MHC mRNA在6小时后分别升高38.19％，45.61％和74.24％（P <0.05）。运动后Myo-D和肌生成素mRNA分别升高了27.28％和23.58％（P <0.05），但是Id-1 mRNA没有变化。 Myo-D和Myogenin mRNA在6小时后升高分别为46.85％和46.41％（P <0.05），而Id-1没有变化。运动后，Myo-D和肌生成素蛋白分别增加57.91％和52.30％，运动后6 h分别增加317.56％和254.08（P <0.05），而Id-1没有变化。术后6小时肌原纤维蛋白升高84.52％（P <0.05）。 I型和IIa型MHC mRNA在运动后6 h与肌生成素mRNA和蛋白运动后和6 h后相关，而IIx型在6 h后的运动与Myo-D mRNA和蛋白运动后以及6 h后运动相关（P <0.05）。结论：这些结果表明，在一次高强度抗性锻炼后，所有三种MHC亚型的mRNA表达均上调，并且Myo-D和肌生成素似乎在MHC亚型基因表达中起作用。

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