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首页> 外文期刊>Medicine and science in sports and exercise >Effects of iontophoretic versus injection administration of dexamethasone.
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Effects of iontophoretic versus injection administration of dexamethasone.

机译：地塞米松的离子电渗疗法与注射给药的关系。

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PURPOSE: Sixty-eight skeletally mature New Zealand white rabbits were used to study the effects of iontophoresis- and injection-delivered sodium phosphate dexamethasone (DX) on the morphologic, histologic, microscopic, and biomechanical properties of uninjured rabbit patellar tendons over an initial 14-d period. METHODS: Three control (untreated, placebo iontophoresis, and placebo injection) groups and two treatment (iontophoresis and injection) groups underwent serum, ELISA tendon, histology, electron microscopy, and biomechanical analysis. RESULTS: Serum DX levels were detectable and quantifiable in both treatment groups at 1 h but were significantly greater (P < 0.05) in the injected group (11.29 ng.mL-1) compared with the iontophoresis group (6.34 ng.mL-1). The most significant histologic finding was a lack of a cellular inflammatory response in the DX-treated groups at 24 h. Ultrastructural analysis produced no significant differences between size or size ratio of collagen fibrils among any groups. Morphologic examination revealed only injection puncture marks seen in appropriate tendons. Biomechanical testing produced disruption at the patellar insertion in 81% of the specimens. No injected tendon failed at the injection site. Normalized biomechanical properties included: 1) Stiffness increased in control and iontophoresis groups from 1 to 24 h, then gradually declined; the DX-injected specimens showed a similar but delayed effect. 2) Peak load at failure for iontophoresis and control groups was greatest at 24 h. The DX-injected group again showed a delayed response. 3) In general, total energy to failure revealed no significant differences between groups at any time period. CONCLUSION: It appears that iontophoresis or injection-delivered DX may produce anti-inflammatory effects without significantly altering ultrastructural or biomechanical characteristics of the rabbit patellar tendon within an initial 14-d period.
机译：目的：以68只骨骼成熟的新西兰白兔为研究对象，研究了离子电渗疗法和注射方式递送的磷酸地塞米松钠（DX）对最初14天内未受伤的rabbit骨肌腱的形态，组织学，微观和生物力学特性的影响。 -d期。方法：对三个对照组（未治疗，安慰剂离子电渗疗法和安慰剂注射）组和两个治疗组（离子电渗疗法和注射液）进行血清，ELISA肌腱，组织学，电子显微镜和生物力学分析。结果：两个治疗组在1 h时血清DX水平均可检测和定量，但与离子电渗疗法组（6.34 ng.mL-1）相比，注射组（11.29 ng.mL-1）显着更高（P <0.05）。 。最重要的组织学发现是DX治疗组在24小时内缺乏细胞炎症反应。在任何组中，超微结构分析在胶原原纤维的尺寸或尺寸比之间均没有显着差异。形态学检查仅在适当的肌腱中可见注射穿刺痕迹。生物力学测试在81％的样本的the骨插入处产生破坏。没有注射肌腱在注射部位失败。归一化的生物力学特性包括：1）对照组和离子电渗疗法组的刚度从1到24小时增加，然后逐渐下降; DX注射的标本显示出相似但延迟的效果。 2）离子电渗疗法和对照组失败时的峰值负荷在24 h时最大。注射DX的组再次显示出延迟反应。 3）总的来说，失败的总能量在任何时间段内均未显示组之间的显着差异。结论：离子电渗疗法或注射传递的DX可能在最初的14天之内没有明显改变兔pa腱的超微结构或生物力学特性的情况下产生抗炎作用。

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