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首页> 外文期刊>Medicine and science in sports and exercise >Energy Expenditure and Plasma F2-Isoprostanes across the Menstrual Cycle.
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Energy Expenditure and Plasma F2-Isoprostanes across the Menstrual Cycle.

机译：月经周期中的能量消耗和血浆F2-异前列腺素。

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INTRODUCTION:: Habitual energy expenditure seems to favorably alter oxidant/antioxidant balance. Sparse evidence suggests that hormones that fluctuate during the menstrual cycle, particularly estrogens, may influence concentrations of oxidative biomarkers and their relation to energy expenditure. METHODS:: We investigated the relation between energy expenditure and plasma free F2-isoprostane concentrations in 259 healthy, regularly menstruating 18- to 44-yr-old participants of the BioCycle Study. Habitual energy expenditure was measured using a baseline International Physical Activity Questionnaire and categorized as low, moderate, or high. Women were followed for one or two subsequent menstrual cycles. Past-week and past-day physical activity were measured during follow-up using questionnaires and diaries, respectively. F2-isoprostane concentrations were measured in blood samples collected at both menses (approximate cycle day 2; low serum estradiol concentration) and the late follicular phase (approximate cycle day 12; peak estradiol concentration). Generalized estimating equations were used to model the energy expenditure/isoprostane association, adjusting for confounders. RESULTS:: Habitual energy expenditure was positively associated with F2-isoprostane concentration (adjusted difference in median F2-isoprostane, high versus low energy expenditure: 17.4%; 95% confidence interval (CI) = 3.3%-31.4%). This association was not modified by cycle phase (interaction, P = 0.61) or differences in peak estradiol concentration across women (interaction, P = 0.20). Past-week and past-day physical activity measures were not associated with F2-isoprostane concentration (category trend, P = 0.50 and P = 0.18, respectively). CONCLUSIONS:: These results suggest that higher habitual energy expenditure may be associated with higher concentration of F2-isoprostanes in healthy, reproductive-aged women. Estradiol concentration changes during the menstrual cycle do not seem to influence this relationship.
机译：简介：习惯性的能源消耗似乎可以有利地改变氧化剂/抗氧化剂的平衡。稀少的证据表明，在月经周期内波动的激素，尤其是雌激素，可能会影响氧化生物标志物的浓度及其与能量消耗的关系。方法：我们调查了259名健康，定期经期18至44岁的BioCycle研究参与者的能量消耗与血浆游离F2-异前列腺素浓度之间的关系。习惯性能源支出是使用基线《国际体育锻炼问卷》进行测量的，分为低，中或高。跟踪妇女的月经周期为一到两个。在随访期间分别使用问卷和日记来测量过去一周和过去一天的体育活动。在月经（大约第2天周期;血清雌二醇浓度较低）和卵泡晚期（大约第12天周期;雌二醇峰值浓度）采集的血样中测量F2-异前列腺素浓度。通用估计方程用于对能量消耗/异前列烷烃关联进行建模，并针对混杂因素进行调整。结果：习惯性的能量消耗与F2-异前列腺素浓度呈正相关（F2-异前列腺素中位数调整后的差异，高能量消耗与低能量消耗：17.4％; 95％置信区间（CI）= 3.3％-31.4％）。这种关联并未因周期阶段（相互作用，P = 0.61）或女性雌二醇峰值浓度的差异（相互作用，P = 0.20）而改变。过去一周和过去一天的体育锻炼量度与F2-异前列腺素浓度无关（类别趋势，P = 0.50和P = 0.18）。结论：这些结果表明，在健康的生殖年龄妇女中，较高的习惯性能量消耗可能与F2-异前列腺素的较高浓度有关。月经周期中雌二醇浓度的变化似乎并不影响这种关系。

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