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首页> 外文期刊>Medical engineering & physics. >Individual and combined effects of OA-related subchondral bone alterations on proximal tibial surface stiffness: a parametric finite element modeling study
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Individual and combined effects of OA-related subchondral bone alterations on proximal tibial surface stiffness: a parametric finite element modeling study

机译：OA相关软骨下骨改变对胫骨近端表面硬度的个体和综合作用：参数有限元建模研究

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摘要

The role of subchondral bone in OA pathogenesis is unclear. While some OA-related changes to morphology and material properties in different bone regions have been described, the effect of these alterations on subchondral bone surface stiffness has not been investigated. The objectives of this study were to characterize the individual (Objective 1) and combined (Objective 2) effects of OA-related morphological and mechanical alterations to subchondral and epiphyseal bone on surface stiffness of the proximal tibia. We developed and validated a parametric FE model of the proximal tibia using quantitative CT images of 10 fresh-frozen cadaveric specimens and in situ macro-indentation testing. Using this validated FE model, we estimated the individual and combined roles of OA-related alterations in subchondral cortical thickness and elastic modulus, and subchondral trabecular and epiphyseal trabecular elastic moduli on local surface stiffness. A 20% increase in subchondral cortical or subchondral trabecular elastic moduli resulted in little change in stiffness (1% increase). A 20% reduction in epiphyseal trabecular elastic modulus, however, resulted in an 11% reduction in stiffness. Our parametric analysis suggests that subchondral bone stiffness is affected primarily by epiphyseal trabecular bone elastic modulus rather than subchondral cortical and trabecular morphology or mechanical properties. Our results suggest that observed OA-related alterations to epiphyseal trabecular bone (e.g., lower mineralization, bone volume fraction, density and elastic modulus) may contribute to OA proximal tibiae being less stiff than normal. (C) 2015 IPEM. Published by Elsevier Ltd. All rights reserved.
机译：软骨下骨在OA发病机理中的作用尚不清楚。虽然已经描述了在不同骨区域中一些与OA相关的形态和材料特性变化，但尚未研究这些变化对软骨下骨表面硬度的影响。这项研究的目的是表征与骨关节炎相关的形态学和机械改变对软骨下骨和骨s骨的OA（单个目标）和联合（目标2）对胫骨近端表面硬度的影响。我们使用10个新鲜冷冻尸体标本的定量CT图像和原位宏观压痕测试，开发并验证了胫骨近端的参数化FE模型。使用此经过验证的有限元模型，我们估计了与OA相关的改变在软骨下皮质厚度和弹性模量以及软骨下小梁和骨s小梁的弹性模量对局部表面硬度的个体作用和综合作用。软骨下皮质或软骨下小梁弹性模量增加20％，导致刚度变化很小（增加1％）。但是，epi骨小梁的弹性模量降低了20％，刚度降低了11％。我们的参数分析表明，软骨下骨的刚度主要受epi骨小梁骨弹性模量的影响，而不是软骨下皮层和小梁的形态或力学性能。我们的结果表明，观察到的与OA相关的骨epi小梁骨变化（例如，矿化度降低，骨体积分数，密度和弹性模量降低）可能导致OA胫骨近端的僵硬程度低于正常情况。 （C）2015年IPEM。由Elsevier Ltd.出版。保留所有权利。

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